DACTIM-MIS, Laboratory of Mathematics and Applications (LMA), UMR CNRS 7348, University of Poitiers, CHU de Poitiers, 86021 Poitiers, France.
Centre de Recherche Clinique, Grand Hôpital de l'Est Francilien (GHEF), 77100 Meaux, France.
Int J Mol Sci. 2020 Jan 27;21(3):820. doi: 10.3390/ijms21030820.
Age-related macular degeneration (AMD) is considered as the main worldwide cause of blindness in elderly adults. Exudative AMD type represents 10 to 15% of macular degeneration cases, but is the main cause of vision loss and blindness. Circadian rhythm changes are associated with aging and could further accelerate it. However, the link between circadian rhythms and exudative AMD is not fully understood. Some evidence suggests that dysregulation of circadian functions could be manifestations of diseases or could be risk factors for the development of disease in elderly adults. Biological rhythms are complex systems interacting with the environment and control several physiological pathways. Recent findings have shown that the dysregulation of circadian rhythms is correlated with exudative AMD. One of the main pathways involved in exudative AMD is the canonical WNT/β-catenin pathway. Circadian clocks have a main role in some tissues by driving the circadian expression of genes involved in physiological and metabolic functions. In exudative AMD, the increase of the canonical WNT/β-catenin pathway is enhanced by the dysregulation of circadian rhythms. Exudative AMD progression is associated with major metabolic reprogramming, initiated by aberrant WNT/β-catenin pathway, of aerobic glycolysis. This review focuses on the interest of circadian rhythm dysregulation in exudative AMD through the aberrant upregulation of the canonical WNT/β-catenin pathway.
年龄相关性黄斑变性（AMD）被认为是导致老年人失明的主要全球原因。渗出型 AMD 占黄斑变性病例的 10% 至 15%，但却是视力丧失和失明的主要原因。昼夜节律变化与衰老有关，并可能进一步加速衰老。然而，昼夜节律与渗出型 AMD 之间的联系尚未完全阐明。有证据表明，昼夜节律功能失调可能是疾病的表现，也可能是老年人疾病发展的危险因素。生物节律是与环境相互作用的复杂系统，控制着几种生理途径。最近的研究结果表明，昼夜节律失调与渗出型 AMD 有关。参与渗出型 AMD 的主要途径之一是经典的 WNT/β-catenin 途径。昼夜节律钟在一些组织中起着主要作用，通过驱动参与生理和代谢功能的基因的昼夜表达。在渗出型 AMD 中，昼夜节律失调会增强经典的 WNT/β-catenin 途径的增加。渗出型 AMD 的进展与有氧糖酵解的主要代谢重编程有关，这是由异常的 WNT/β-catenin 途径引发的。本综述通过异常上调经典的 WNT/β-catenin 途径，重点探讨了昼夜节律失调在渗出型 AMD 中的作用。
