FONG J, CHIN D, ELBERG S S
J Exp Med. 1964 Nov 1;120(5):885-95. doi: 10.1084/jem.120.5.885.
Comparison of the Brucella-immune and the BCG-immune histiocyte, each of which is resistant to necrotization by either Brucella or mycobacteria, has revealed a number of dissimilarities in their behavior. The Brucella-immune histiocyte was found to be incapable of transferring its resistance to the cells of normal animals; it was also unable to achieve attenuation of virulent tubercle bacilli. In contrast, the BCG-immune histiocyte and certain of its subcellular components (ribosomes and ribosomal RNA) were effective in inducing cellular resistance in normal animals against both Brucella and mycobacteria. When RNA was used, only immune ribosomal RNA was effective; when intact ribosomes were used, both immune and recipient ribosomes proved active. These investigations have also shown that the resistance of the BCG-immune histiocyte against Brucella and mycobacteria was of long duration and not readily dissociable.
对布鲁氏菌免疫组织细胞和卡介苗免疫组织细胞进行比较,发现它们各自对布鲁氏菌或分枝杆菌引起的坏死均具有抗性,但在行为上存在一些差异。研究发现,布鲁氏菌免疫组织细胞无法将其抗性传递给正常动物的细胞;它也无法使强毒结核杆菌减毒。相比之下,卡介苗免疫组织细胞及其某些亚细胞成分(核糖体和核糖体RNA)能有效诱导正常动物对布鲁氏菌和分枝杆菌产生细胞抗性。当使用RNA时,只有免疫核糖体RNA有效;当使用完整核糖体时,免疫核糖体和受体核糖体均表现出活性。这些研究还表明,卡介苗免疫组织细胞对布鲁氏菌和分枝杆菌的抗性持续时间长,且不易解离。