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结核杆菌与单核细胞关系的研究。II. 细菌和培养滤液诱导单核细胞变性：血清和单核细胞对变性抗性影响的特异性。

Studies on tubercle bacillus-monocyte relationship. II. Induction of monocyte degeneration by bacteria and culture filtrate: specificity of serum and monocyte effects on resistance to degeneration.

作者信息

ELBERG S S, FONG J, SCHNEIDER P

出版信息

J Exp Med. 1957 Jan 1;105(1):25-37. doi: 10.1084/jem.105.1.25.

DOI:10.1084/jem.105.1.25

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2136668/

Abstract

Studies of virulent, attenuated, and avirulent strains of tubercle bacilli have demonstrated the proficiency of virulent strains to effect degeneration of normal monocytes cultivated in the presence of normal serum. Attenuated strains were less active in this respect, and avirulent bacilli failed to induce monocytic degeneration. Comparison of the effects of virulent H37Rv with O.T., P.P.D., and a culture filtrate of H37Rv revealed a similarity in action of H37Rv and its filtrate. The action of O.T. and P.P.D. differed from that of H37Rv in that the greatest effect of H37Rv was upon normal cells as opposed to the effect of O.T. and P.P.D. upon immune cells. Additionally, it was demonstrated that immune serum (anti-BCG) protected immune cells against H37Rv but not against O.T. or P.P.D. The protection of immune cells by heterologous antisera (anti-Salmonella and anti-ovalbumin) as well as by homologous antiserum (anti-BCG) against the degenerative effects of H37Rv indicated a non-specificity in action of serum factors. The ability of the monocytes of animals immunized with BCG and the failure of monocytes of animals immunized with Salmonella rutgers to withstand parasitization with H37Rv, when both types of monocytes were cultivated in immune (anti-BCG) serum, indicated a specificity of cellular resistance.

摘要

对结核杆菌的强毒株、减毒株和无毒株的研究表明，强毒株能够使在正常血清存在下培养的正常单核细胞发生变性。减毒株在这方面活性较低，无毒杆菌则不能诱导单核细胞变性。对强毒株H37Rv与旧结核菌素（O.T.）、结核菌纯蛋白衍生物（P.P.D.）以及H37Rv培养滤液的作用进行比较，发现H37Rv及其滤液的作用相似。O.T.和P.P.D.的作用与H37Rv不同，因为H37Rv对正常细胞的作用最大，而O.T.和P.P.D.对免疫细胞的作用最大。此外，还证明免疫血清（抗卡介苗血清）可保护免疫细胞免受H37Rv的侵害，但不能保护其免受O.T.或P.P.D.的侵害。异种抗血清（抗沙门氏菌血清和抗卵清蛋白血清）以及同种抗血清（抗卡介苗血清）对免疫细胞的保护作用，使其免受H37Rv的变性作用，这表明血清因子的作用具有非特异性。当在免疫（抗卡介苗）血清中培养时，用卡介苗免疫的动物的单核细胞能够抵抗H37Rv的寄生，而用鲁氏沙门氏菌免疫的动物的单核细胞则不能，这表明细胞抗性具有特异性。