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[高血压状态下红细胞中钙离子结合及钠钾ATP酶功能特性的变化]

[Changes in calcium ion binding and characteristics of Na+, K+-ATPase functioning in erythrocytes in the presence of hypertension].

作者信息

Postnov Iu V, Orlov S N, Shevchenko A S

出版信息

Biull Eksp Biol Med. 1977 Jul;84(7):41-4.

PMID:142533
Abstract

A greater amount of calcium is removed with the aid of EDTA from the erythrocyte membranes of patients with hypertensive disease than from erythrocytes of persons with a normal arterial blood pressure. When isotonic MgCl2 was used the amount of calcium removed from the erythrocytic membrane was equal in both groups. The activity of Na-K-ATP-ase in the membrane of reconstituted erythrocytes increased with the action of calcium ions in the patients with hypertensive disease only half as much as in healthy persons.

摘要

与动脉血压正常者的红细胞相比,借助乙二胺四乙酸(EDTA)从高血压病患者的红细胞膜中去除的钙量更多。当使用等渗氯化镁时,两组从红细胞膜中去除的钙量相等。仅在高血压病患者中,重构红细胞膜中钠钾ATP酶的活性随钙离子作用的增加幅度仅为健康人的一半。

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