肠道病毒的光动力灭活
PHOTODYNAMIC INACTIVATION OF ENTEROVIRUSES.
作者信息
WALLIS C, MELNICK J L
出版信息
J Bacteriol. 1965 Jan;89(1):41-6. doi: 10.1128/jb.89.1.41-46.1965.
Wallis, Craig (Baylor University College of Medicine, Houston, Tex.), and Joseph L. Melnick. Photodynamic inactivation of enteroviruses. J. Bacteriol. 89:41-46. 1965.-Enteroviruses are usually resistant to photodynamic inactivation, but they can be rendered completely photosensitive to proflavine at pH 9 to 10, if they are first purified by filtration through an anion resin. In addition, if enteroviruses are grown in cells maintained in a salt-glucose medium, they can be photosensitized. Of 38 enteroviruses tested, 10 were rendered completely photosensitive to proflavine, or toluidine blue, or both, and the remaining 28 viruses were sensitized, but to a lesser degree. The binding of dye to the virus can be reversed by lowering the pH.
沃利斯，克雷格（贝勒医学院，得克萨斯州休斯顿）和约瑟夫·L·梅尔尼克。肠道病毒的光动力灭活。《细菌学杂志》89:41 - 46。1965年。——肠道病毒通常对光动力灭活有抗性，但如果首先通过阴离子树脂过滤纯化，它们在pH 9至10时可对原黄素完全感光。此外，如果肠道病毒在盐 - 葡萄糖培养基中培养的细胞中生长，它们可以被光敏化。在测试的38种肠道病毒中，10种对原黄素或甲苯胺蓝或两者完全感光，其余28种病毒被致敏，但程度较轻。降低pH值可使染料与病毒的结合逆转。
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