Moore C, Wallis C, Melnick J L, Kuns M D
Infect Immun. 1972 Feb;5(2):169-71. doi: 10.1128/iai.5.2.169-171.1972.
Photodynamic inactivation of virus was tested as a potential therapeutic tool for herpesvirus-induced keratitis, which is a leading cause of blindness and disability. Experimental keratitis produced in rabbits by infection with herpesvirus isolated from a human periorbital lesion was treated with proflavine and light. The herpetic keratitis could be rapidly resolved by the dye-light treatment, whereas improvement was not seen in untreated rabbits, nor in those treated with light alone or dye alone.
光动力病毒灭活作为疱疹病毒引起的角膜炎的一种潜在治疗手段进行了测试，疱疹病毒引起的角膜炎是失明和残疾的主要原因。用从人类眶周病变中分离出的疱疹病毒感染兔子产生实验性角膜炎，然后用原黄素和光进行治疗。通过染料-光治疗，疱疹性角膜炎可迅速消退，而未治疗的兔子、仅用光治疗的兔子或仅用染料治疗的兔子均未见病情改善。
