Roos J, Plas-Roser S, Hassani M, Aron C
C R Seances Soc Biol Fil. 1977;171(2):446-50.
An increase in peripheral blood progesterone concentration was observed in diestrus II, at 17:30 in 4-day cyclic female rats subcutaneously injected with 10 microgram estradiol benzoate (EB) at 10:00-11:00 on diestrus I. Pentobarbital injection (30 mg/kg) at 13:30 on diestrus II did not prevent this effect on EB. By contrast PB injected at 13:30 on diestrus II as above completely suppressed the luteinizing or ovulating effects of EB. The action of estrogen on blood progesterone level was therefore concluded to be unrelated to the mechanisms underlying estrogen-induced ovulation luteinization in the cyclic female rat.
在间情期II观察到外周血孕酮浓度升高，对于在间情期I的10:00 - 11:00皮下注射10微克苯甲酸雌二醇（EB）的4天周期雌性大鼠，在间情期II的17:30出现此现象。在间情期II的13:30注射戊巴比妥（30毫克/千克）并不能阻止EB的这种作用。相比之下，如上所述在间情期II的13:30注射PB则完全抑制了EB的促黄体生成或排卵作用。因此得出结论，雌激素对血孕酮水平的作用与周期性雌性大鼠中雌激素诱导排卵黄体化的潜在机制无关。
