Hassani M
C R Seances Soc Biol Fil. 1978;172(1):167-71.
Estrogen-induced changes in peripheral blood progesterone concentration have been studied in dexamethasone (DEX) and metopyrone (MET) treated 4-day cyclic female rats. Estradiol benzoate (EB) was injected at 10--11 h on diestrus I and peripheral blood was collected at 16--17 h on diestrus II for progesterone radioimmunoassay. The EB induced-increase in blood progesterone concentration was more pronounced, compared to non-injected females in intact DEX-treated females and in adrenalectomized females treated or not with DEX than in their intact counterparts. The adrenal cortex was then supposed to inhibit the luteotrophic action of EB. When injected for 10--12 days, MET caused an increase in blood progesterone concentration compared to uninjected control animals. No cumulative effects of EB and MET were observed. These results are discussed in the light of knowledge, on the feed-back mechanisms which are involved in the action of estrogen on the pituitary-ovarian-adrenocortical system.
已在接受地塞米松（DEX）和甲吡酮（MET）治疗的4天周期雌性大鼠中研究了雌激素诱导的外周血孕酮浓度变化。在动情间期I的10 - 11小时注射苯甲酸雌二醇（EB），并在动情间期II的16 - 17小时采集外周血用于孕酮放射免疫测定。与未注射的完整雌性大鼠相比，在完整的DEX治疗雌性大鼠以及接受或未接受DEX治疗的肾上腺切除雌性大鼠中，EB诱导的血液孕酮浓度升高更为明显。于是推测肾上腺皮质会抑制EB的促黄体生成作用。当注射10 - 12天时，与未注射的对照动物相比，MET导致血液孕酮浓度升高。未观察到EB和MET的累积效应。根据关于雌激素对垂体 - 卵巢 - 肾上腺皮质系统作用所涉及的反馈机制的知识对这些结果进行了讨论。
