Kayser C, Hildwein G
C R Seances Soc Biol Fil. 1977;171(2):450-5.
The effect of three drugs, parachlorophenylalanine, nialamide and disulfiram, drugs known by their action on the two sleep phases, slow wave sleep and I-REM-sleep, have been studied and tested by their effect on the motor circadian rhythm : PCPA and disulfiram reduce the amplitude of the rhythm by two opposed mechanisms : PCPA increases the motor activity, especially the day-time activity, disulfiram reduces the motor activity, especially the night-time activity. The former reduces the serotonine content, the latter the noradrenaline content of the central nervous system. Nialamide (5 or 10 mg/1000 g) is without any action of the rhythm. Both doses increase very much the motor activity ; but the central excitatory state undergoes the normal circadian rhythm. This monoaminoxydase inhibitor is without any action on the circadian rhythm.
三种药物，对氯苯丙氨酸、尼亚酰胺和双硫仑，已知它们对慢波睡眠和快速眼动睡眠这两个睡眠阶段有作用，已通过它们对运动昼夜节律的影响进行了研究和测试：对氯苯丙氨酸和双硫仑通过两种相反的机制降低节律的幅度：对氯苯丙氨酸增加运动活动，尤其是白天的活动，双硫仑降低运动活动，尤其是夜间的活动。前者降低中枢神经系统的血清素含量，后者降低去甲肾上腺素含量。尼亚酰胺（5或10毫克/1000克）对节律没有任何作用。两种剂量都极大地增加了运动活动；但中枢兴奋状态遵循正常的昼夜节律。这种单胺氧化酶抑制剂对昼夜节律没有任何作用。
