Sofikitis N, Takahashi C, Kadowaki H, Okazaki T, Nakamura I, Shimamoto T, Saeki H, Miyagawa I
Department of Urology, Tottori University School of Medicine, Yonago, Japan.
Eur Urol. 1992;22(1):44-52. doi: 10.1159/000474720.
Human chorionic gonadotropin, kallikrein, indomethacin, and hydralazine were administered to different groups of varicocelized rats, while surgical repair of the varicocele was performed in another group of rats. The effects of conservative and surgical treatment on epididymal sperm content and motility, the weights of the testes, epididymis, and male accessory genital glands, and fertility were compared between each group and a sham-treated group of rats. Surgical repair significantly improved all the evaluated parameters and all the conservative regimens, except hydralazine, resulted in a significant improvement in most parameters. Our results indicate that stimulation of the Leydig or/and Sertoli cells of a varicocelized testicle can counteract some of the detrimental consequences of the varicocele itself.
将人绒毛膜促性腺激素、激肽释放酶、吲哚美辛和肼屈嗪分别给予不同组的精索静脉曲张大鼠，而另一组大鼠则进行精索静脉曲张的手术修复。比较了每组大鼠与假手术组大鼠在保守治疗和手术治疗对附睾精子含量和活力、睾丸、附睾和雄性附属生殖腺重量以及生育能力方面的影响。手术修复显著改善了所有评估参数，除肼屈嗪外，所有保守治疗方案在大多数参数上都有显著改善。我们的结果表明，刺激精索静脉曲张睾丸的睾丸间质细胞或/和支持细胞可以抵消精索静脉曲张本身的一些有害后果。
