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多糖对实验性精索静脉曲张大鼠的影响。

Effects of Polysaccharide on Experimental Varicocele Rats.

作者信息

Zhang Lihong, Zhao Xiaozhen, Wang Feng, Lin Qing, Wang Wei

机构信息

Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fujian Medical University, No. 1 Xueyuan Road, Minhou County, Fuzhou, Fujian 350108, China; Research Center for Neurobiology, School of Basic Medical Sciences, Fujian Medical University, No. 1 Xueyuan Road, Minhou County, Fuzhou, Fujian 350108, China.

出版信息

Evid Based Complement Alternat Med. 2016;2016:5365291. doi: 10.1155/2016/5365291. Epub 2016 Dec 20.

DOI:10.1155/2016/5365291
PMID:28090212
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5206431/
Abstract

is a traditional Chinese herbal medicine, which has been used to tonify the kidney and strengthen yang for a long time in China. In this study, the effects of Polysaccharide (MOP) on experimental varicocele adolescent rats were investigated. The result showed that varicocele destroyed the structure of the seminiferous epithelium and decreased the TJ protein expression (Occludin, Claudin-11, and ZO-1), testosterone (T) concentration in the left testicular tissue and serum, and serum levels of inhibin B (INHB), while increasing the levels of cytokines (TGF-3 and TNF-) in the left testicular tissue, as well as serum levels of gonadotropin-releasing hormone (GnRH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and antisperm antibody (AsAb). MOP repaired the damaged seminiferous epithelium and TJ and reduced the levels of cytokines (TGF-3 and TNF-) as well as serum levels of GnRH, FSH, LH, and AsAb, while upregulating TJ protein expression, T level in the left testicular tissue and serum, and serum INHB levels. In summary, we conclude that MOP promotes spermatogenesis and counteracts the varicocele-induced damage to the seminiferous epithelium and TJ, probably via decreasing cytokines (TGF-3 and TNF-) levels and regulating the abnormal sex hormones levels in experimental varicocele rats.

摘要

是一种传统的中草药，在中国长期用于补肾壮阳。在本研究中，研究了麦冬多糖（MOP）对实验性精索静脉曲张青春期大鼠的影响。结果表明，精索静脉曲张破坏了生精上皮的结构，降低了紧密连接蛋白（闭合蛋白、Claudin-11和ZO-1）的表达、左侧睾丸组织和血清中的睾酮（T）浓度以及抑制素B（INHB）的血清水平，同时增加了左侧睾丸组织中细胞因子（转化生长因子β和肿瘤坏死因子α）的水平以及促性腺激素释放激素（GnRH）、卵泡刺激素（FSH）、黄体生成素（LH）和抗精子抗体（AsAb）的血清水平。MOP修复了受损的生精上皮和紧密连接，降低了细胞因子（转化生长因子β和肿瘤坏死因子α）的水平以及GnRH、FSH、LH和AsAb的血清水平，同时上调了紧密连接蛋白的表达、左侧睾丸组织和血清中的T水平以及血清INHB水平。综上所述，我们得出结论，MOP可能通过降低细胞因子（转化生长因子β和肿瘤坏死因子α）水平并调节实验性精索静脉曲张大鼠异常的性激素水平来促进精子发生，并抵消精索静脉曲张对生精上皮和紧密连接的损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/292e/5206431/a31a3e3ce5b3/ECAM2016-5365291.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/292e/5206431/6eac5c94b5ce/ECAM2016-5365291.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/292e/5206431/9eca8b7a9619/ECAM2016-5365291.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/292e/5206431/53585dbee3c7/ECAM2016-5365291.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/292e/5206431/a31a3e3ce5b3/ECAM2016-5365291.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/292e/5206431/6eac5c94b5ce/ECAM2016-5365291.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/292e/5206431/9eca8b7a9619/ECAM2016-5365291.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/292e/5206431/53585dbee3c7/ECAM2016-5365291.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/292e/5206431/a31a3e3ce5b3/ECAM2016-5365291.004.jpg

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Protection against Cyclosporine-Induced Reprotoxicity by Satureja khuzestanica Essential Oil in Male Rats.胡齐斯坦鼠尾草精油对雄性大鼠环孢素诱导的生殖毒性的保护作用。
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