Patsch Janina M, Deutschmann Julia, Pietschmann Peter
Department of Radiology, Medical University of Vienna, Vienna, Austria.
Wien Med Wochenschr. 2011 Mar;161(5-6):117-23. doi: 10.1007/s10354-011-0891-9.
Although postmenopausal and elderly women are more frequently affected by osteoporosis, men are not protected from the disease. Age-related osteoporosis involves several gender-specific clinical aspects such as disease onset time and different dynamics of bone loss. Men benefit from larger bones and a time-delay of age-related changes in bone density and quality. Moreover, secondary osteoporosis is more common in males than in females. High-resolution peripheral quantitative computed tomography (HR-pQCT) and high-resolution magnetic resonance imaging (HR-MRI) represent novel research tools for a noninvasive quantification of bone microstructure which is of interest for musculoskeletal gender studies. For optimal design of such studies, researchers should be aware of technical pitfalls and site-specificity of bone microstructure.
虽然绝经后女性和老年女性更常受到骨质疏松症的影响，但男性也无法免受该疾病的侵害。与年龄相关的骨质疏松症涉及几个特定性别的临床方面，如疾病发病时间和不同的骨质流失动态。男性受益于更大的骨骼以及骨密度和质量与年龄相关变化的时间延迟。此外，继发性骨质疏松症在男性中比在女性中更常见。高分辨率外周定量计算机断层扫描（HR-pQCT）和高分辨率磁共振成像（HR-MRI）代表了用于非侵入性量化骨微结构的新型研究工具，这对肌肉骨骼性别研究具有重要意义。为了此类研究的最佳设计，研究人员应了解骨微结构的技术陷阱和部位特异性。
