Sahota O, Masud T, San P, Hosking D J
Ageing and Disability Research Unit, University Hospital, Nottingham, UK.
Clin Endocrinol (Oxf). 1999 Aug;51(2):217-21. doi: 10.1046/j.1365-2265.1999.00764.x.
The aim of this study was to determine whether the presence of vitamin D insufficiency increases bone turnover and enhances bone loss by examining the relationship between bone turnover markers and Bone mineral density (BMD) in vitamin D insufficient and vitamin D sufficient patients, with established vertebral osteoporosis.
119 consecutive, active, community dwelling, elderly women were assessed over a 7-month period between the months of March to October.
There was a significant correlation between parathyroid hormone (PTH) and 25 hydroxyvitamin D (25(OH)D), r = - 0. 42 (P < 0.01). The prevalence of vitamin D insufficiency was 26.9% (defined by a 25(OH)D >/= 6.1 microg/l and </= 12 microg/l). This resulted in a statistically significant increase in bone turnover markers compared to the vitamin D sufficient group: bone alkaline phosphatase (P < 0.05), osteocalcin (P < 0.01), hydroxyproline (P < 0.05), free deoxypyridinoline (P < 0.05) and lower bone mineral density at the total hip (P < 0.01).
These results show that there is a high prevalence of vitamin D insufficiency in the active community dwelling elderly with established vertebral osteoporosis presenting to clinical attention, which leads to increased bone turnover, decreased BMD at the hip and thus enhanced risk of further osteoporotic fractures in comparison with vitamin D sufficient subjects.
本研究旨在通过检测维生素D不足和维生素D充足的已确诊椎体骨质疏松患者的骨转换标志物与骨密度（BMD）之间的关系，确定维生素D不足是否会增加骨转换并加剧骨质流失。
在3月至10月的7个月期间，对119名连续的、活跃的、居住在社区的老年女性进行了评估。
甲状旁腺激素（PTH）与25羟维生素D（25(OH)D）之间存在显著相关性，r = -0.42（P < 0.01）。维生素D不足的患病率为26.9%（定义为25(OH)D≥6.1微克/升且≤12微克/升）。与维生素D充足组相比，这导致骨转换标志物在统计学上显著增加：骨碱性磷酸酶（P < 0.05）、骨钙素（P < 0.01）、羟脯氨酸（P < 0.05）、游离脱氧吡啶啉（P < 0.05），且全髋部骨密度降低（P < 0.01）。
这些结果表明，在前来临床就诊的已确诊椎体骨质疏松的活跃社区居住老年人中，维生素D不足的患病率很高，与维生素D充足的受试者相比，这会导致骨转换增加、髋部骨密度降低，从而增加进一步发生骨质疏松性骨折的风险。
