Berlin I, Molinier P, Duchier A, Cournot A, Durrel J, Dellatolas F, Duchier J
Therapharm Recherches, Boulogne, France.
Eur J Clin Pharmacol. 1992;43(2):117-9. doi: 10.1007/BF01740655.
The effects of single doses and of 7 days of lansoprazole 10, 20 and 30 mg PO versus placebo on gastric acid secretion have been evaluated in 8 patients with high gastric acid secretion. The double blind crossover period was followed by a simple blind 7 days on placebo to detect any rebound phenomenon. After the first dose lansoprazole did not modify basal acid output (BAO) but it significantly and dose dependently inhibited peak acid output (PAO) and increased the time during which nocturnal intragastric pH was greater than 3. After 7 days of treatment the same significant, dose-dependent suppression of gastric acid was found, but BAO was also blocked. One week after cessation of lansoprazole administration no rebound increase in gastric acid-secretion was observed. The plasma gastrin concentration remained unchanged throughout the study.
在8名胃酸分泌过多的患者中，评估了口服10、20和30毫克兰索拉唑单剂量以及连续7天给药与安慰剂相比对胃酸分泌的影响。双盲交叉期之后是为期7天的简单盲法安慰剂治疗，以检测任何反弹现象。首次给药后，兰索拉唑未改变基础酸排量（BAO），但显著且剂量依赖性地抑制了高峰酸排量（PAO），并延长了夜间胃内pH值大于3的时间。治疗7天后，发现胃酸受到同样显著的剂量依赖性抑制，且BAO也被阻断。停用兰索拉唑给药一周后，未观察到胃酸分泌的反弹增加。在整个研究过程中，血浆胃泌素浓度保持不变。
