Constanti A, Libri V
Department of Pharmacology, School of Pharmacy, London, U.K.
Eur J Pharmacol. 1992 Jun 17;216(3):463-4. doi: 10.1016/0014-2999(92)90450-i.
The metabotropic glutamate receptor agonist trans-(+/-)-1-amino-1,3-cyclopentanedicarboxylic acid (trans-ACPD) produced a slow, persistent excitation of guinea-pig olfactory cortical neurones in vitro, and the appearance of a prominent post-stimulus after depolarization. The corresponding slow inward tail current (IADP) revealed under voltage clamp was insensitive to tetrodotoxin (or atropine) but was blocked by Cd2+ or tetrabutylammonium. The IADP properties resembled those of the slow inward tail current induced by muscarinic agonists in these neurones, suggesting a common intracellular transduction mechanism.
促代谢型谷氨酸受体激动剂反式-(+/-)-1-氨基-1,3-环戊烷二羧酸（反式-ACPD）在体外对豚鼠嗅觉皮层神经元产生缓慢、持续的兴奋作用，并在去极化后出现明显的刺激后电位。在电压钳制下揭示的相应缓慢内向尾电流（IADP）对河豚毒素（或阿托品）不敏感，但被Cd2+或四丁铵阻断。IADP的特性类似于这些神经元中由毒蕈碱激动剂诱导的缓慢内向尾电流的特性，提示存在共同的细胞内转导机制。
