Capková J, Ivanyi P
Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Praha.
Folia Biol (Praha). 1992;38(3-4):258-62.
Joint disease, ankylosing enthesopathy (ANKENT) of the ankle, occurs naturally in mice. ANKENT depends on the genetical constitution, sex, and age, and its frequency varies among inbred strains of normal mice. We found the highest frequency of ANKENT in B10.BR (H-2k) males. The H-2k haplotype appears to be a relative risk factor, which increases the susceptibility to ANKENT. The aetiology of ANKENT is unknown but an involvement of microbial agents in the environment is supposed.
关节疾病，踝关节强直性附着点病（ANKENT），可自然发生于小鼠。ANKENT取决于遗传构成、性别和年龄，其发生率在正常小鼠的近交系中有所不同。我们发现B10.BR（H-2k）雄性小鼠中ANKENT的发生率最高。H-2k单倍型似乎是一个相对风险因素，它增加了对ANKENT的易感性。ANKENT的病因尚不清楚，但推测环境中的微生物因素与之有关。
