Roxburgh J C, Whitfield P F, Hobsley M
Department of Surgery, University College and Middlesex School of Medicine, London.
Gut. 1992 Sep;33(9):1170-3. doi: 10.1136/gut.33.9.1170.
The effects of smoking one cigarette on a plateau of submaximal gastric secretion induced by histamine acid phosphate (16 nmol kg-1 h-1 (0.005 mg kg-1 h-1)) were measured in eight normal volunteers and in eight duodenal ulcer subjects. The rate of secretion in both groups fell by 25% without any statistically significant change in pyloric loss or duodenogastric reflux. It is concluded that smoking reduces gastric secretion. The possibility that relative antral hypoacidity induced by regular smoking produces an increase in parietal cell mass via a feedback mechanism mediated by gastrin is discussed: such a mechanism would explain the previously reported positive correlation between maximal gastric secretion of acid and the total dose of cigarettes.
在8名正常志愿者和8名十二指肠溃疡患者中,测量了吸一支香烟对由磷酸组胺(16纳摩尔/千克/小时(0.005毫克/千克/小时))诱导的次最大胃酸分泌平台的影响。两组的分泌速率均下降了25%,幽门损失或十二指肠-胃反流无任何统计学上的显著变化。得出的结论是,吸烟会减少胃酸分泌。讨论了长期吸烟引起的相对胃窦低酸度通过胃泌素介导的反馈机制导致壁细胞数量增加的可能性:这样一种机制可以解释先前报道的胃酸最大分泌量与香烟总剂量之间的正相关关系。