尼古丁对胃黏膜血流及胃酸分泌的影响。
Effect of nicotine on gastric mucosal blood flow and acid secretion.
作者信息
Sonnenberg A, Hüsmert N
出版信息
Gut. 1982 Jun;23(6):532-5. doi: 10.1136/gut.23.6.532.
Abstract
The effects of an intravenous infusion of nicotine at a dose of 2 . 5, 5 . 0, 7 . 5, or 10 . 0 micrograms kg-1h-1 on pentagastrin-stimulated gastric mucosal blood flow and acid secretion were investigated in eight healthy male non-smokers. Each dose was tested in two males. Gastric neutral red clearance served as a measure of mucosal blood flow. Nicotine reduced volume secretion, acid secretion, and neutral red clearance in a dose dependent manner. In five healthy male smokers smoking of five cigarettes per two hours induced similar changes to the intravenous infusion of 5 micrograms kg-1h-1 nicotine. As volume secretion was inhibited more than neutral red clearance, it is concluded that nicotine increases blood supply to the gastric mucosa relatively to the reduced gastric secretion. Nicotine is either not associated with the development of peptic ulcers, or it exerts its ulcerogenic action via other mechanisms than change of acid secretion and gastric mucosal blood flow.
摘要
在8名健康男性非吸烟者中，研究了以2.5、5.0、7.5或10.0微克/千克/小时的剂量静脉输注尼古丁对五肽胃泌素刺激的胃黏膜血流和胃酸分泌的影响。每个剂量在两名男性中进行测试。胃中性红清除率作为黏膜血流的指标。尼古丁以剂量依赖的方式减少了胃液分泌、胃酸分泌和中性红清除率。在5名每两小时吸5支烟的健康男性吸烟者中，引起了与静脉输注5微克/千克/小时尼古丁相似的变化。由于胃液分泌比中性红清除率受到的抑制更大，得出的结论是，相对于减少的胃分泌，尼古丁增加了胃黏膜的血液供应。尼古丁要么与消化性溃疡的发生无关，要么其致溃疡作用是通过改变胃酸分泌和胃黏膜血流以外的其他机制发挥的。
相似文献
1
Effect of nicotine on gastric mucosal blood flow and acid secretion.尼古丁对胃黏膜血流及胃酸分泌的影响。
Gut. 1982 Jun;23(6):532-5. doi: 10.1136/gut.23.6.532.
2
Somatostatin increases the ratio between gastric mucosal blood flow and gastric acid and pepsin secretion in dogs.
Scand J Gastroenterol. 1986 Mar;21(2):215-20. doi: 10.3109/00365528609034649.
3
Dissociated effect of nicotine on pentagastrin-stimulated acid secretion and blood flow in the rat stomach.尼古丁对大鼠胃中五肽胃泌素刺激的胃酸分泌和血流的解离作用。
Scand J Gastroenterol. 1994 Sep;29(9):782-5. doi: 10.3109/00365529409092510.
4
Gastric mucosal blood flow response to stimulation and inhibition of gastric acid secretion.胃黏膜血流对胃酸分泌刺激和抑制的反应。
Gastroenterology. 1988 Sep;95(3):642-50. doi: 10.1016/s0016-5085(88)80010-6.
5
Dissociated effects of somatostatin on gastric acid secretion and mucosal blood flow.生长抑素对胃酸分泌和黏膜血流的分离效应。
Am J Physiol. 1985 Mar;248(3 Pt 1):G337-41. doi: 10.1152/ajpgi.1985.248.3.G337.
6
Effects of intracerebroventricularly applied nicotine on enhanced gastric acid secretion and mucosal blood flow in rats.脑室内注射尼古丁对大鼠胃酸分泌增强及黏膜血流的影响。
Eur J Pharmacol. 1984 Jun 1;101(3-4):185-91. doi: 10.1016/0014-2999(84)90155-9.
7
The influence of acute or chronic nicotine treatment on ethanol-induced gastric mucosal damage in rats.急性或慢性尼古丁处理对大鼠乙醇诱导的胃黏膜损伤的影响。
Dig Dis Sci. 1990 Jan;35(1):106-12. doi: 10.1007/BF01537231.
8
Gastric hyperemia accompanying acid secretion is not mediated by sensory nerves.伴随胃酸分泌的胃充血并非由感觉神经介导。
Dig Dis Sci. 1993 Jul;38(7):1190-4. doi: 10.1007/BF01296066.
9
Somatostatin reduces gastric mucosal blood flow in normal subjects but not in patients with cirrhosis of the liver.生长抑素可减少正常受试者的胃黏膜血流量，但对肝硬化患者无效。
Gut. 1983 Feb;24(2):148-53. doi: 10.1136/gut.24.2.148.
10
The involvement of histamine receptor subtypes in gastric acid secretion and mucosal blood flow in the anaesthetized rabbit.组胺受体亚型在麻醉兔胃酸分泌和黏膜血流中的作用
J Physiol. 1981 Feb;311:431-42. doi: 10.1113/jphysiol.1981.sp013595.
引用本文的文献
1
Effects of Cigarette Smoke Exposure on the Gut Microbiota and Liver Transcriptome in Mice Reveal Gut-Liver Interactions.香烟烟雾暴露对小鼠肠道微生物群和肝脏转录组的影响揭示了肠道-肝脏相互作用。
Int J Mol Sci. 2022 Sep 20;23(19):11008. doi: 10.3390/ijms231911008.
2
Cigarettes' use and capabilities-opportunities-motivation-for-behavior model: a multi-country survey of adolescents and young adults.香烟使用和能力-机会-动机-行为模型：青少年和年轻成年人的多国调查。
Front Public Health. 2022 Jul 22;10:875801. doi: 10.3389/fpubh.2022.875801. eCollection 2022.
3
Parental Knowledge and Attitude Regarding E-Cigarette Use in Saudi Arabia and the Effect of Parental Smoking: A Cross-Sectional Study.沙特阿拉伯父母对电子烟使用的认知与态度以及父母吸烟的影响：一项横断面研究。
Risk Manag Healthc Policy. 2020 Aug 18;13:1195-1205. doi: 10.2147/RMHP.S253749. eCollection 2020.
4
Harmful effects of nicotine.尼古丁的有害影响。
Indian J Med Paediatr Oncol. 2015 Jan-Mar;36(1):24-31. doi: 10.4103/0971-5851.151771.
5
Dysregulation of gastric H,K-ATPase by cigarette smoke extract.香烟烟雾提取物对胃H，K-ATP酶的调节异常。
World J Gastroenterol. 2009 Aug 28;15(32):4016-22. doi: 10.3748/wjg.15.4016.
6
Acute effects of high-dose intragastric nicotine on mucosal defense mechanisms: an analysis of nicotine, prostaglandin E2, phospholipase A2, and phospholipids.高剂量胃内尼古丁对黏膜防御机制的急性影响：尼古丁、前列腺素E2、磷脂酶A2和磷脂的分析
Dig Dis Sci. 1997 Mar;42(3):640-4. doi: 10.1023/a:1018823815665.
7
Smoking and the digestive system.吸烟与消化系统
J Gastroenterol. 1995 Dec;30(6):803-8. doi: 10.1007/BF02349653.
8
Nicotine has no effect on rat gastric mucosal prostaglandin generation in vitro.尼古丁在体外对大鼠胃黏膜前列腺素的生成没有影响。
Dig Dis Sci. 1993 Aug;38(8):1450-2. doi: 10.1007/BF01308602.
9
Cigarette smoking, gastric acid secretion, and serum pepsinogen I concentrations in duodenal ulcer patients.十二指肠溃疡患者的吸烟情况、胃酸分泌及血清胃蛋白酶原I浓度
Gut. 1985 Dec;26(12):1327-32. doi: 10.1136/gut.26.12.1327.
10
Cigarette smoking reduces human gastric luminal prostaglandin E2.吸烟会降低人体胃腔内前列腺素E2的水平。
Gut. 1985 Nov;26(11):1192-6. doi: 10.1136/gut.26.11.1192.
本文引用的文献
1
THE CIRCULATION OF THE STOMACH.胃的血液循环
Gastroenterology. 1965 Jan;48:85-109.
2
Effect of smoking on the production and maintenance of gastric and duodenal ulcers.吸烟对胃和十二指肠溃疡形成及维持的影响。
Lancet. 1958 Mar 29;1(7022):657-62. doi: 10.1016/s0140-6736(58)91083-3.
3
The gastric secretion of drugs: a pH partition hypothesis.药物的胃分泌：pH分配假说
J Pharmacol Exp Ther. 1957 Mar;119(3):361-9.
4
The effect of histamine and histamine antagonists on gastric acid secretion and mucosal blood flow in man.组胺及组胺拮抗剂对人体胃酸分泌和黏膜血流的影响。
Br J Surg. 1980 Apr;67(4):266-8. doi: 10.1002/bjs.1800670412.
5
Does gastric aminopyrine clearance reflect gastric mucosal blood flow or parietal cell function?胃氨基比林清除率反映胃黏膜血流还是壁细胞功能？
Gut. 1981 Dec;22(12):997-1002. doi: 10.1136/gut.22.12.997.
6
Influence of smoking on healing rate of duodenal ulcer in response to cimetidine or high-dose antacid.吸烟对十二指肠溃疡在西咪替丁或高剂量抗酸剂治疗下愈合率的影响。
Gastroenterology. 1981 Jun;80(6):1451-3.
7
Predictors of duodenal ulcer healing and relapse.十二指肠溃疡愈合与复发的预测因素。
Gastroenterology. 1981 Dec;81(6):1061-7.
8
Effect of 16-16-dimethyl-prostaglandin E2 on ulceration of isolated amphibian gastric mucosa.16-16-二甲基前列腺素E2对离体两栖类动物胃黏膜溃疡形成的影响。
Gastroenterology. 1980 Jun;78(6):1508-12.
9
Gastric secretion in relation to mucosal blood flow studied by a clearance technic.用清除技术研究胃分泌与粘膜血流的关系。
J Clin Invest. 1966 Jan;45(1):1-13. doi: 10.1172/JCI105313.
10
Mechanisms of nicotine-induced inhibition of pancreatic secretion of bicarbonate in the dog.尼古丁对犬胰腺碳酸氢盐分泌抑制作用的机制
Gastroenterology. 1972 Mar;62(3):425-9.
Zotero 插件