Sonnenberg A, Hüsmert N
Gut. 1982 Jun;23(6):532-5. doi: 10.1136/gut.23.6.532.
The effects of an intravenous infusion of nicotine at a dose of 2 . 5, 5 . 0, 7 . 5, or 10 . 0 micrograms kg-1h-1 on pentagastrin-stimulated gastric mucosal blood flow and acid secretion were investigated in eight healthy male non-smokers. Each dose was tested in two males. Gastric neutral red clearance served as a measure of mucosal blood flow. Nicotine reduced volume secretion, acid secretion, and neutral red clearance in a dose dependent manner. In five healthy male smokers smoking of five cigarettes per two hours induced similar changes to the intravenous infusion of 5 micrograms kg-1h-1 nicotine. As volume secretion was inhibited more than neutral red clearance, it is concluded that nicotine increases blood supply to the gastric mucosa relatively to the reduced gastric secretion. Nicotine is either not associated with the development of peptic ulcers, or it exerts its ulcerogenic action via other mechanisms than change of acid secretion and gastric mucosal blood flow.
在8名健康男性非吸烟者中，研究了以2.5、5.0、7.5或10.0微克/千克/小时的剂量静脉输注尼古丁对五肽胃泌素刺激的胃黏膜血流和胃酸分泌的影响。每个剂量在两名男性中进行测试。胃中性红清除率作为黏膜血流的指标。尼古丁以剂量依赖的方式减少了胃液分泌、胃酸分泌和中性红清除率。在5名每两小时吸5支烟的健康男性吸烟者中，引起了与静脉输注5微克/千克/小时尼古丁相似的变化。由于胃液分泌比中性红清除率受到的抑制更大，得出的结论是，相对于减少的胃分泌，尼古丁增加了胃黏膜的血液供应。尼古丁要么与消化性溃疡的发生无关，要么其致溃疡作用是通过改变胃酸分泌和胃黏膜血流以外的其他机制发挥的。
