Schröcksnadel H, Sitte B, Alge A, Steckel-Berger G, Schwegel P, Pastner E, Daxenbichler G, Hansen H, Dapunt O
Department of Obstetrics and Gynecology, University of Innsbruck, Austria.
Gynecol Obstet Invest. 1992;34(3):146-50. doi: 10.1159/000292748.
In a prospective, randomized, double-blind study for the prevention of pregnancy-induced hypertension and preeclampsia, 41 primigravidae with positive roll-over test (28th-32nd week of pregnancy) received 80 mg aspirin/day or placebo until the end of the 37th week. In the patients treated with acetylsalicylic acid (n = 22), 3 cases of proteinuria occurred, but no hypertensive pregnancy complication. In the placebo group (n = 19), 10 patients developed pregnancy-induced hypertension (6 of them preeclampsia). Group-specific differences concerning the occurrence of hypertension were statistically highly significant (p = 0.0004). No relevant differences were observed with regard to pregnancy duration, birth weight and umbilical artery pH value. The placebo group included 1 intrauterine death. No increased tendency to maternal or fetal bleeding was noticed.
在一项预防妊娠高血压和先兆子痫的前瞻性、随机、双盲研究中，41例翻身试验阳性（妊娠28至32周）的初产妇每天服用80毫克阿司匹林或安慰剂，直至妊娠37周末。在接受乙酰水杨酸治疗的患者（n = 22）中，发生了3例蛋白尿，但无高血压妊娠并发症。在安慰剂组（n = 19）中，10例患者发生了妊娠高血压（其中6例为先兆子痫）。高血压发生率的组间差异具有高度统计学意义（p = 0.0004）。在妊娠持续时间、出生体重和脐动脉pH值方面未观察到相关差异。安慰剂组有1例宫内死亡。未发现母婴出血倾向增加。
