Herrera J A
Family Health Department, School of Medicine, Universidad del Valle, Cali, Colombia.
Int J Gynaecol Obstet. 1993 Apr;41(1):31-5. doi: 10.1016/0020-7292(93)90151-l.
The possibility of reducing pregnancy-induced hypertension and preeclampsia in primigravidas with low doses of nutritional factors and relative rest in the left lateral position was investigated in a randomized controlled, double-blind trial.
Seventy-four normotensive women at 28-29 weeks' gestation, judged to be at risk of PIH or pre-eclampsia because they presented with a mean blood pressure of 80 mmHg or higher and a positive roll-over test, were studied. The treatment protocol was received by 37 women and the other 37 women received standard antenatal control until delivery.
Twenty-nine (78.3%) women in the control group developed PIH and/or pre-eclampsia, as opposed to only 4 (10.8%) cases in the treatment group (P < 0.001). There were no adverse effects of treatment in mothers or in infants.
This protocol reduces PIH and pre-eclampsia in primigravidas judged to be at risk of hypertension. Further studies are required to evaluate prostacyclin and prostaglandin E2 changes.
在一项随机对照双盲试验中，研究了低剂量营养因子及相对左侧卧位休息对降低初产妇妊娠高血压和子痫前期的可能性。
研究了74名妊娠28至29周的血压正常女性，这些女性因平均血压80 mmHg或更高且翻身试验呈阳性而被判定有患妊娠高血压或子痫前期的风险。37名女性接受了治疗方案，另外37名女性接受标准产前检查直至分娩。
对照组中有29名（78.3%）女性发生了妊娠高血压和/或子痫前期，而治疗组中只有4例（10.8%）（P < 0.001）。治疗对母亲或婴儿均无不良影响。
该方案可降低被判定有高血压风险的初产妇的妊娠高血压和子痫前期。需要进一步研究来评估前列环素和前列腺素E2的变化。
