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抗原诱导的环磷酰胺抗性抑制性T细胞可抑制单向混合白细胞反应中细胞毒性细胞的体外生成。

Antigen-induced cyclophosphamide-resistant suppressor T cells inhibit the in vitro generation of cytotoxic cells from one-way mixed leukocyte reactions.

作者信息

Bonavida B

出版信息

J Immunol. 1977 Oct;119(4):1530-3.

PMID:142792
Abstract

Mice sensitized against a tumor allograft and given cyclophosmamide 6 days later failed to generate an immune response to the allograft. Spleen cells derived from these mice suppressed the generation of cytotoxic T cell response by normal spleen cells in mixed leukocyte cultures. The suppressor cells were not specific, thymus dependent, and resistant to 2000 R.

摘要

对肿瘤同种异体移植物致敏的小鼠，6天后给予环磷酰胺，未能对同种异体移植物产生免疫反应。来自这些小鼠的脾细胞在混合白细胞培养物中抑制了正常脾细胞的细胞毒性T细胞反应的产生。抑制细胞是非特异性的，依赖胸腺，且对2000伦琴有抗性。

相似文献

1
Antigen-induced cyclophosphamide-resistant suppressor T cells inhibit the in vitro generation of cytotoxic cells from one-way mixed leukocyte reactions.抗原诱导的环磷酰胺抗性抑制性T细胞可抑制单向混合白细胞反应中细胞毒性细胞的体外生成。
J Immunol. 1977 Oct;119(4):1530-3.
2
Restoration of cyclophosphamide-induced suppression of thymus-derived cytotoxic cell generation by normal thymocytes.正常胸腺细胞对环磷酰胺诱导的胸腺来源细胞毒性细胞生成抑制的恢复作用。
Cancer Res. 1979 Sep;39(9):3647-54.
3
Sequential mechanisms of cyclophosphamide-induced skin allograft tolerance including the intrathymic clonal deletion followed by late breakdown of the clonal deletion.环磷酰胺诱导皮肤同种异体移植耐受的连续机制，包括胸腺内克隆清除，随后克隆清除出现晚期瓦解。
J Immunol. 1990 Sep 1;145(5):1303-10.
4
Suppressor cells in the spleen of tumor-allosensitized mice.肿瘤同种致敏小鼠脾脏中的抑制细胞。
Cancer Res. 1977 Sep;37(9):3390-9.
5
Cytotoxic effects of antigen- and mitogen-induced T cells on various targets.抗原和丝裂原诱导的T细胞对各种靶标的细胞毒性作用。
J Immunol. 1975 Feb;114(2 Pt 1):559-65.
6
Tumor-specific suppressor T-cells which inhibit the in vitro generation of cytolytic T-cells from immune and early tumor-bearing host spleens.肿瘤特异性抑制性T细胞，其可抑制从免疫宿主和早期荷瘤宿主脾脏中体外产生细胞毒性T细胞。
Cancer Res. 1986 Apr;46(4 Pt 1):1805-12.
7
Suppressor cells in tumor-bearing mice capable of nonspecific blocking of in vitro immunization against transplant antigens.荷瘤小鼠体内能够非特异性阻断针对移植抗原的体外免疫的抑制细胞。
J Immunol. 1975 May;114(5):1554-6.
8
Regulation of cytotoxic lymphocyte responses in vitro by alloantigen-activated spleen cells.同种抗原激活的脾细胞对体外细胞毒性淋巴细胞反应的调节
J Immunol. 1977 Jul;119(1):31-7.
9
Interaction between T cells and non-T cells in suppression of cytotoxic lymphocyte responses.T细胞与非T细胞在抑制细胞毒性淋巴细胞反应中的相互作用。
J Immunol. 1979 Aug;123(2):745-50.
10
A monoclonal antibody that recognizes an Ly-6-linked antigen inhibits the generation of functionally active T cell subsets.一种识别Ly-6相关抗原的单克隆抗体可抑制功能活性T细胞亚群的产生。
J Immunol. 1985 Jul;135(1):63-72.

引用本文的文献

1
Activation of human B lymphocytes. XII. Differential effects of in vitro cyclophosphamide on human lymphocyte subpopulations involved in B-cell activation.人B淋巴细胞的激活。十二。体外环磷酰胺对参与B细胞激活的人淋巴细胞亚群的不同作用。
Immunology. 1980 Mar;39(3):391-7.
2
The effects of cyclophosphamide on in vitro cytotoxic responses to a syngeneic tumour.环磷酰胺对同基因肿瘤体外细胞毒性反应的影响。
Cancer Immunol Immunother. 1982;14(1):54-8. doi: 10.1007/BF00199433.
3
Regulation of specific cell-mediated cytotoxic response against SV40-induced tumor associated antigens by depletion of suppressor T cells with cyclophosphamide in mice.
用环磷酰胺耗尽小鼠体内的抑制性T细胞对SV40诱导的肿瘤相关抗原的特异性细胞介导细胞毒性反应的调节
J Exp Med. 1979 Mar 1;149(3):774-9. doi: 10.1084/jem.149.3.774.