同种异体移植耐受中的体外反应性：高度耐受大鼠中混合淋巴细胞培养反应性的持续性
In vitro reactivity in allograft tolerance: persistence of mixed leukocyte culture reactivity in highly tolerant rats.
作者信息
Wright P W, Loop S M, Bernstein I D
出版信息
J Immunol. 1977 Oct;119(4):1538-41.
PMID:142793
Abstract
Mixed leukocyte culture reactivity was studied in adult W/Fu rats judged to be highly tolerant after the inoculation of (W/Fu X BN)F1 hybrid spleen and bone marrow cells at birth. Reactivity was observed in a majority of tolerant donors tested and documented by quantitative dose-response and kinetic studies. Allograft tolerance cannot be explained by a complete lack of specific immune reactivity to tolerated alloantigens.
摘要
在出生时接种了（W/Fu×BN）F1杂种脾细胞和骨髓细胞后被判定为高度耐受的成年W/Fu大鼠中，研究了混合白细胞培养反应性。在大多数接受测试的耐受供体中观察到了反应性，并通过定量剂量反应和动力学研究进行了记录。同种异体移植耐受不能用对耐受同种异体抗原完全缺乏特异性免疫反应性来解释。
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