Durga R, Sridhar P, Polasa H
Department of Microbiology, Osmania University, Hyderabad.
Indian J Med Res. 1992 Apr;96:143-5.
This paper reports the antimutagenic activity of plumbagin (5-hydroxy-2-methyl-1, 4-naphthoquinone) against certain known chemical mutagens in a standard mutagenicity test system of Ames using S. typhimurium strains. Plumbagin by itself did not show any mutagenic effect, whereas it reduced significantly the mutagenic effect of 4-nitrophenylene diammine, phenyl hydrazine and sodium azide in test strains of S. typhimurium, suggesting that plumbagin possessed antimutagenic activity.
本文报道了在使用鼠伤寒沙门氏菌菌株的Ames标准致突变性测试系统中，白花丹醌（5-羟基-2-甲基-1,4-萘醌）对某些已知化学诱变剂的抗诱变活性。白花丹醌本身未显示出任何诱变作用，而在鼠伤寒沙门氏菌测试菌株中，它显著降低了4-硝基苯二胺、苯肼和叠氮化钠的诱变作用，表明白花丹醌具有抗诱变活性。
