Sanchez Bayle M, Gonzalez Vergaz A, Garcia Cuartero B, Santos Tapia M, Gonzalez Requejo A
Hospital del Niño Jesus, Madrid, Spain.
Int J Cardiol. 1992 Sep;36(3):267-71. doi: 10.1016/0167-5273(92)90295-e.
The relationship between hyperlipidemia and a parental history of heart attack and other related disorders was studied in 2224 two- to 18-yr-old children in Madrid (Spain). Children were divided into three groups: those with a parental history of heart attack (first group), a parental history of stroke, hypertension, diabetes mellitus or hypercholesterolemia (second group), and no parental history of disease (third group). The number of children with higher than normal levels of total cholesterol (greater than 200 mg/dl), LDL-cholesterol (greater than 135 mg/dl) and/or apolipoprotein B100 (greater than 75 mg/dl) was significantly higher in the first and second group (positive parental history) than in the third (no parental history). Children and adolescents with a parental history of heart attack (first group) had significantly higher mean levels of total cholesterol and LDL-cholesterol; in the 2- to 13-yr age group a significantly higher level of apolipoprotein B was also found. Children and adolescents belonging to the second group had a significantly higher level of LDL-cholesterol, and a significantly higher level of apolipoprotein B was also found in the 2- to 13-yr age group. However, only 15% of children with hypercholesterolemia had a parental history of heart attack or other related disorders. This percentage was 41% when second-degree relatives were included in the family history. We conclude that a parental history is not enough to detect children with an abnormal lipid profile who might be at risk for early development of coronary arterial disease.
在西班牙马德里的2224名2至18岁儿童中，研究了高脂血症与心脏病发作家族史及其他相关疾病之间的关系。儿童被分为三组：有心脏病发作家族史的儿童（第一组）、有中风、高血压、糖尿病或高胆固醇血症家族史的儿童（第二组）以及无疾病家族史的儿童（第三组）。第一组和第二组（有阳性家族史）中总胆固醇水平高于正常（大于200mg/dl）、低密度脂蛋白胆固醇水平高于正常（大于135mg/dl）和/或载脂蛋白B100水平高于正常（大于75mg/dl）的儿童数量显著高于第三组（无家族史）。有心脏病发作家族史的儿童和青少年（第一组）的总胆固醇和低密度脂蛋白胆固醇平均水平显著更高；在2至13岁年龄组中，载脂蛋白B水平也显著更高。属于第二组的儿童和青少年的低密度脂蛋白胆固醇水平显著更高，在2至13岁年龄组中，载脂蛋白B水平也显著更高。然而，只有15%的高胆固醇血症儿童有心脏病发作或其他相关疾病的家族史。当家族史中包括二级亲属时，这一比例为41%。我们得出结论，家族史不足以检测出可能有冠状动脉疾病早期发病风险的血脂异常儿童。
