生物示踪数据分析中一种算子方法的研究
INVESTIGATION OF AN OPERATOR METHOD IN THE ANALYSIS OF BIOLOGICAL TRACER DATA.
作者信息
MYHILL J, WADSWORTH G P, BROWNELL G L
出版信息
Biophys J. 1965 Jan;5(1):89-107. doi: 10.1016/s0006-3495(65)86704-2.
Some factors affecting the usefulness of a linear operator in the analysis of tracer data were evaluated. Application of the operator to a sum of two exponential components resulted in the separation of the rate constants with an accuracy of 10 to 15 per cent if they differed by a factor of at least 2 and the error in the data was about 2 per cent. A factor of 4 was necessary if the error in the data was 6 per cent, and of 6 if the error was 10 per cent. The ratio of amplitudes varied from near unity to equality with the ratio of rate constants. However, if the ratio of amplitudes was greater than the ratio of rate constants the method would not resolve the rate constants. Application of the operator to a sum of three exponential components was also considered.
评估了一些影响线性算子在示踪剂数据分析中效用的因素。如果两个指数成分之和的速率常数相差至少2倍，且数据误差约为2%，将该算子应用于这两个指数成分之和时，可将速率常数分离，其精度为10%至15%。如果数据误差为6%，则需要相差4倍；如果误差为10%，则需要相差6倍。振幅比从接近1到与速率常数比相等不等。然而，如果振幅比大于速率常数比，该方法将无法分辨速率常数。还考虑了将该算子应用于三个指数成分之和的情况。
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