人体中的锂动力学：给药模式变化的影响。
Lithium kinetics in man: effect of variation in dosage pattern.
作者信息
Bergner P E, Berniker K, Cooper T B, Gradijan J R, Simpson G M
出版信息
Br J Pharmacol. 1973 Oct;49(2):328-39. doi: 10.1111/j.1476-5381.1973.tb08380.x.
Abstract
- Utilizing a general stochastic theory of drug kinetics we have demonstrated that from the serum concentration curve derived from a single dose of lithium, it is possible to predict the steady state concentration, the time required to reach steady state, the dependency of these quantities on the time interval between drug administrations and the fluctuations in plasma level under steady state conditions.2. It has been shown in general that the more frequently the drug is administered the higher is the steady state level, the shorter is the time required to reach steady state, and the smaller are the fluctuations.
摘要
- 利用药物动力学的一般随机理论，我们已经证明，从单次剂量锂的血清浓度曲线可以预测稳态浓度、达到稳态所需的时间、这些量对给药时间间隔的依赖性以及稳态条件下血浆水平的波动情况。2. 一般来说，已经表明给药频率越高，稳态水平越高，达到稳态所需的时间越短，波动越小。
相似文献
1
Lithium kinetics in man: effect of variation in dosage pattern.人体中的锂动力学：给药模式变化的影响。
Br J Pharmacol. 1973 Oct;49(2):328-39. doi: 10.1111/j.1476-5381.1973.tb08380.x.
2
Steady-state lithium blood level fluctuations in man following administration of a lithium carbonate conventional and controlled-release dosage form.给予碳酸锂常规剂型和控释剂型后人体中锂的稳态血药浓度波动情况。
J Clin Pharmacol. 1981 Feb-Mar;21(2):106-9. doi: 10.1002/j.1552-4604.1981.tb01758.x.
3
Prediction of lithium carbonate dosage in psychiatric inpatients using the repeated one-point method.采用重复单点法预测精神科住院患者碳酸锂剂量
Clin Pharm. 1983 May-Jun;2(3):243-8.
4
Lithium test-dose methodology using flame photometry: problems and alternatives.使用火焰光度法的锂试验剂量方法：问题与替代方法
J Clin Psychiatry. 1983 Jan;44(1):7-9.
5
Prediction of therapeutic lithium dose: comparison and improvement of current methods.治疗性锂剂量的预测：当前方法的比较与改进
J Clin Psychiatry. 1987 Jul;48(7):284-6.
6
The utility of a single-point dosing protocol for predicting steady-state lithium levels.单点给药方案预测锂稳态水平的效用。
Br J Psychiatry. 1986 Apr;148:401-5. doi: 10.1192/bjp.148.4.401.
7
Theophylline-lithium interaction.茶碱与锂的相互作用。
J Clin Psychiatry. 1985 Jul;46(7):278-9.
8
Absorption and disposition kinetics of lithium carbonate following administration of conventional and controlled release formulations.碳酸锂常规制剂和控释制剂给药后的吸收与处置动力学
Int J Clin Pharmacol Ther Toxicol. 1986 May;24(5):240-5.
9
Lithium dosage regimen design by the repeated one-point method.采用重复单点法设计锂盐给药方案。
Arzneimittelforschung. 1982;32(2):98-102.
10
Correction of lithium levels for dose and blood sampling times.根据剂量和采血时间校正锂水平。
J Clin Psychiatry. 1987 Feb;48(2):60-4.
引用本文的文献
1
Modulation of G/PLC-Mediated Signaling by Acute Lithium Exposure.急性锂暴露对G/磷脂酶C介导信号传导的调节作用。
Front Cell Neurosci. 2022 Feb 15;16:838939. doi: 10.3389/fncel.2022.838939. eCollection 2022.
2
Lithium pharmacokinetics: single-dose experiments and analysis using a physiological model.锂的药代动力学：单剂量实验及使用生理模型的分析
J Pharmacokinet Biopharm. 1980 Oct;8(5):439-61. doi: 10.1007/BF01059545.
3
Lithium's inhibition of erythrocyte cation countertransport involves a slow process in the erythrocyte.锂对红细胞阳离子逆向转运的抑制作用涉及红细胞内的一个缓慢过程。
J Membr Biol. 1983;75(3):233-40. doi: 10.1007/BF01871954.
4
Blood levels and management of lithium treatment.锂治疗的血药浓度及管理
Br Med J. 1974 Sep 14;3(5932):650-4. doi: 10.1136/bmj.3.5932.650.
5
Computer assisted prescribing of drugs.计算机辅助药物处方
Clin Pharmacokinet. 1976;1(1):67-78. doi: 10.2165/00003088-197601010-00006.
6
A priori lithium dosage regimen using population characteristics of pharmacokinetic parameters.利用药代动力学参数的人群特征制定的先验锂剂量方案。
J Pharmacokinet Biopharm. 1979 Dec;7(6):579-628. doi: 10.1007/BF01061210.
本文引用的文献
1
INVESTIGATION OF AN OPERATOR METHOD IN THE ANALYSIS OF BIOLOGICAL TRACER DATA.生物示踪数据分析中一种算子方法的研究
Biophys J. 1965 Jan;5(1):89-107. doi: 10.1016/s0006-3495(65)86704-2.
2
Dosage schedule and pharmacokinetics in chemotherapy.化疗中的给药方案与药代动力学
J Am Pharm Assoc Am Pharm Assoc. 1960 May;49:311-3.
3
Application of isotope derivative technique to assay of secondary amines: estimation of desipramine by acetylation with H3-acetic anhydride.同位素衍生技术在仲胺测定中的应用：用H3-乙酸酐乙酰化法测定地昔帕明
J Pharmacol Exp Ther. 1967 Sep;157(3):503-8.
4
Blood levels of drug at the equilibrium state after multiple dosing.多次给药后达到平衡状态时药物的血药浓度。
Nature. 1965 Sep 18;207(5003):1301-2. doi: 10.1038/2071301a0.
5
Tracer dynamics and the determination of pool-sizes and turnover factors in metabolic systems.示踪动力学与代谢系统中池大小和周转因子的测定
J Theor Biol. 1964 Mar;6(2):137-58. doi: 10.1016/0022-5193(64)90025-6.
6
Multicompartment-kinetics and the accumulation plateau.多室动力学与蓄积平台期。
Arch Int Pharmacodyn Ther. 1970 Nov;188(1):200-3.
7
Clinical-chemical correlations: an overview.临床化学相关性：概述
Psychopharmacol Bull. 1970 Jan;6(1):26-33.
8
Factors affecting chlorpromazine plasma levels in psychiatric patients.影响精神病患者氯丙嗪血药浓度的因素。
Arch Gen Psychiatry. 1970 Mar;22(3):209-15. doi: 10.1001/archpsyc.1970.01740270017002.
Zotero 插件