Martin X D, Fankhauser F, Rabineau P A
University of Zurich, Department of Ophthalmology, Switzerland.
Int Ophthalmol. 1992 Sep;16(4-5):325-9. doi: 10.1007/BF00917985.
This single-blind, randomized study investigated the effects of unilateral instillation of 0.5% maleate timolol twice a day for 7 days on visual-field parameters of both eyes. Twelve normal, young subjects (30.6 +/- 4.2 years) participated in this study. Using program G1 of the Octopus 500 automated perimeter, the visual fields were measured one week and one day before therapy and a third time one week after beginning therapy. The paired T-test was used for statistical analysis, where a P-value < or = 0.05 indicated significance. Whereas nothing statistically significant was found in the treated eyes, the contralateral, untreated eyes showed a statistically significant decrease of mean sensitivity between the first visual fields and the third ones (P < 0.01) This diminution of mean sensitivity in the untreated contralateral eyes may be due to statistically significant lowering of blood pressure (P < 0.01) and slowing of cardiac frequency, which were not compensated by a local decrease of intraocular pressure. If confirmed, these findings could be of clinical importance in the management of glaucoma patients, since some authors have, in some cases, recommended a unilateral therapy.
这项单盲随机研究调查了每天两次单侧滴注0.5%马来酸噻吗洛尔，共7天，对双眼视野参数的影响。12名正常年轻受试者（30.6±4.2岁）参与了本研究。使用Octopus 500自动视野计的G1程序，在治疗前一周和一天以及开始治疗一周后第三次测量视野。采用配对t检验进行统计分析，P值≤0.05表示有统计学意义。虽然在治疗眼中未发现统计学上的显著差异，但对侧未治疗眼在第一次和第三次视野测量之间平均敏感度有统计学上的显著下降（P<0.01）。未治疗对侧眼平均敏感度的降低可能是由于血压有统计学上的显著降低（P<0.01）和心率减慢，而眼压的局部降低并未对此起到代偿作用。如果得到证实，这些发现可能在青光眼患者的治疗中具有临床重要性，因为一些作者在某些情况下推荐单侧治疗。
