Martin X D, Rabineau P A
Department of Ophthalmology, Basel University, Switzerland.
Ophthalmology. 1988 Dec;95(12):1620-3. doi: 10.1016/s0161-6420(88)32966-0.
Beta-adrenergic antagonists are generally considered to lower intraocular pressure (IOP) of both eyes after unilateral instillation. In order to determine whether timolol also lowers IOP in the contralateral eye and to what extent, pressure curves were established in 14 normal, young subjects. Eye pressure curves on both eyes of each subject were measured before and 1 week after timolol 0.5% instillation twice daily in one eye. All subjects had an IOP decrease in the treated eye, but no subjects had a statistically significant IOP decrease in the contralateral eye. The mean IOP reduction was 26% in the treated eye, and only 3% in the contralateral eye. These results suggest that, in most cases, timolol does not lower IOP in the contralateral eye after unilateral instillation in normal subjects in contrast to certain glaucoma patients. These results suggest two different actions for timolol: (1) a local action in the treated eye, and (2) a systemic action where the pressure-lowering effect in the untreated eye is significant only in some pathologic conditions.
β - 肾上腺素能拮抗剂通常被认为在单侧滴眼后可降低双眼的眼压。为了确定噻吗洛尔是否也能降低对侧眼的眼压以及降低的程度，我们对14名正常的年轻受试者进行了眼压曲线测定。在一只眼睛每日两次滴注0.5%噻吗洛尔之前和之后1周，测量了每个受试者双眼的眼压曲线。所有受试者的治疗眼眼压均降低，但对侧眼眼压降低均无统计学意义。治疗眼眼压平均降低26%，而对侧眼仅降低3%。这些结果表明，在大多数情况下，与某些青光眼患者不同，正常受试者单侧滴注噻吗洛尔后对侧眼眼压并不降低。这些结果提示噻吗洛尔有两种不同作用：(1) 对治疗眼的局部作用；(2) 全身作用，即未治疗眼的降压作用仅在某些病理情况下显著。
