Nadal D, Soh N, Schläpfer E, Bernstein J M, Ogra P L
Department of Pediatrics, State University of New York, Buffalo School of Medicine.
Int J Pediatr Otorhinolaryngol. 1992 Sep;24(2):121-30. doi: 10.1016/0165-5876(92)90138-f.
Forty-four adenoids and 52 palatine tonsils from 71 children and adolescents (age 3-21 years) undergoing surgery because of adenoidal hypertrophy or recurrent tonsillitis were examined for the presence of immunoglobulin-secreting cells (ISC) employing an enzyme-linked immunospot assay (ELISPOT). ISC constituted less than 2% of the mononuclear cell population. Adenoids contained IgG, IgA, and IgM ISC in significantly lower numbers than palatine tonsils. The predominant isotype of the ISC was IgG, in adenoids accounting for 62% of the ISC and in palatine tonsils for 73%. The relative numbers for IgA and IgM ISC were similar. A significant correlation existed between autologous adenoids and palatine tonsils for the numbers of IgA and IgM ISC, but not for the numbers of IgG cells. These observations suggest that, adenoid and palatine tonsils display similar immunoglobulin distribution patterns within a single individual. However, individuals with hypertrophied adenoids exhibited a numeric decrease in IgG ISC with increasing age (P less than 0.01). Both lymphoid tissues may be involved in mucosal immune defense.
对71名因腺样体肥大或复发性扁桃体炎而接受手术的儿童和青少年（年龄3 - 21岁）的44个腺样体和52个腭扁桃体进行检查，采用酶联免疫斑点试验（ELISPOT）检测免疫球蛋白分泌细胞（ISC）的存在情况。ISC占单核细胞群体的比例不到2%。腺样体中IgG、IgA和IgM ISC的数量明显低于腭扁桃体。ISC的主要同种型是IgG，在腺样体中占ISC的62%，在腭扁桃体中占73%。IgA和IgM ISC的相对数量相似。自体腺样体和腭扁桃体中IgA和IgM ISC的数量之间存在显著相关性，但IgG细胞数量之间不存在相关性。这些观察结果表明，腺样体和腭扁桃体在个体内显示出相似的免疫球蛋白分布模式。然而，腺样体肥大的个体中，IgG ISC的数量随年龄增长而减少（P小于0.01）。这两种淋巴组织可能都参与黏膜免疫防御。
