Sanders C L
Washington State University at Tri-Cities, Richland.
Health Phys. 1992 Dec;63(6):695-7. doi: 10.1097/00004032-199212000-00012.
Pleural mesothelioma was an infrequent observation following deposition of 239PuO2 in the lung or pleural cavity. Only five tumors were found in 2,105 rats exposed to 239PuO2 aerosols in the present study, while four tumors were found in 527 rats that inhaled 239PuO2 in previously published lifespan studies. Risk of pleural mesothelioma was not significantly increased by intrapleural injection of 30 kBq 239PuO2. In contrast, a much higher incidence of peritoneal mesothelioma was seen following intraperitoneal injection of 239PuO2 due to aggregation of 239PuO2 particles on mesothelial surfaces. It was concluded that the lack of 239PuO2 aggregation on pleural surfaces is responsible for small numbers of pleural mesothelioma observed following deposition of 239PuO2.
在肺部或胸腔内沉积239PuO2后，胸膜间皮瘤是一种不常见的观察结果。在本研究中，暴露于239PuO2气溶胶的2105只大鼠中仅发现5例肿瘤，而在先前发表的寿命研究中，吸入239PuO2的527只大鼠中发现4例肿瘤。胸膜内注射30 kBq 239PuO2并未显著增加胸膜间皮瘤的风险。相反，由于239PuO2颗粒在间皮表面聚集，腹腔内注射239PuO2后腹膜间皮瘤的发病率要高得多。得出的结论是，胸膜表面缺乏239PuO2聚集是239PuO2沉积后观察到的胸膜间皮瘤数量较少的原因。
