Sanders C L, McDonald K E, Lauhala K E
Biology and Chemistry Department, Pacific Northwest Laboratory, Richland, WA 99352.
Int J Radiat Biol. 1988 Jul;54(1):115-21. doi: 10.1080/09553008814551551.
Aggregation of inhaled 239PuO2 particles in the pulmonary region of the lung may be required for promotion of pulmonary carcinogenesis in rats. Female Wistar rats were exposed to an aerosol of 239PuO2 and their lungs examined by scanning electron microscopic (SEM) autoradiography. SEM autoradiography provides a rapid and inexpensive method for viewing a large lung tissue volume for alpha tracks. Evidence of particle aggregation was seen by 28 days postinhalation and was marked by 90 to 150 days post-inhalation. Subpleural plutonium particles resulted in exposure into the pleural cavity. Peribronchiolar, alveolar plutonium particles and particle aggregates gave the greatest radiation dose to the bronchiolar epithelium. High-dose, overlapping, alpha-track, radiation zones in bronchiolar epithelium may be required for maximum development of lung tumors.
为促进大鼠肺部致癌作用，可能需要吸入的239PuO2颗粒在肺部区域聚集。将雌性Wistar大鼠暴露于239PuO2气溶胶中，并通过扫描电子显微镜（SEM）放射自显影检查其肺部。SEM放射自显影为观察大体积肺组织中的α径迹提供了一种快速且廉价的方法。吸入后28天可见颗粒聚集迹象，在吸入后90至150天更为明显。胸膜下钚颗粒导致暴露于胸膜腔。细支气管周围、肺泡内的钚颗粒及颗粒聚集体对细支气管上皮产生的辐射剂量最大。细支气管上皮中高剂量、重叠的α径迹辐射区可能是肺部肿瘤充分发展所必需的。
