Ognjan A F, Lewandowski C A, Belian B T, Burczak J, Markowitz N, Lee H, Saravolatz L D
Department of Emergency Medicine, Henry Ford Hospital, Detroit, MI 48202.
Henry Ford Hosp Med J. 1992;40(1-2):131-5.
During 1987-1988, a seroprevalence study of the human immunodeficiency virus (HIV-1) and the human T-cell lymphoma/leukemia virus (HTLV-I/II) was performed among Detroit intravenous drug users unaffiliated with substance abuse programs. Seroprevalence data along with patient demographic information were compared to a similar study performed in 1985-1986. In the earlier study, 12 (12.5%) of 96 individuals tested positive for HIV-1. Of the 74 available negative samples retested in 1987-1988 for retroviruses, 7 (9.5%) tested positive for HTLV-I/II. Thus, the overall retroviral (HIV-1, HTLV-I/II) seropositive rate for 1985-1986 was 22%. In 1987-1988, 11 (15.7%) of 70 individuals tested positive for HIV-1 and 7 (10%) tested positive for HTLV-I/II. Concomitant infection with both viruses was found in 2 (2.9%) of the 70 individuals. Thus, retrovirus seroprevalence in 1987-1988 was 22.9%. In 1987-1988, significant differences between the retroviral-positive group and the retroviral-negative group consisted of intravenous drug use greater than 16 years (P = 0.059) for an odds ratio of 3.80 (CI 1.12-12.89) and sex with female prostitutes (P = 0.029) for an odds ratio of 5.38 (CI 1.38-20.95).
1987年至1988年期间，在底特律未参加药物滥用项目的静脉注射吸毒者中开展了一项人类免疫缺陷病毒（HIV-1）和人类T细胞淋巴瘤/白血病病毒（HTLV-I/II）血清流行率研究。将血清流行率数据及患者人口统计学信息与1985年至1986年开展的一项类似研究进行了比较。在早期研究中，96名个体中有12名（12.5%）HIV-1检测呈阳性。在1987年至1988年对74份可用的逆转录病毒检测阴性样本重新检测时，7份（9.5%）HTLV-I/II检测呈阳性。因此，1985年至1986年的总体逆转录病毒（HIV-1、HTLV-I/II）血清阳性率为22%。1987年至1988年，70名个体中有11名（15.7%）HIV-1检测呈阳性，7名（10%）HTLV-I/II检测呈阳性。在这70名个体中有2名（2.9%）同时感染了这两种病毒。因此，1987年至1988年逆转录病毒血清流行率为22.9%。1987年至1988年，逆转录病毒阳性组和逆转录病毒阴性组之间的显著差异包括静脉注射吸毒超过16年（P = 0.059），优势比为3.80（可信区间1.12 - 12.89），以及与女性妓女发生性行为（P = 0.029），优势比为5.38（可信区间1.38 - 20.95）。
