BOYD E M, SHANAS M N
Can Med Assoc J. 1963 Jul 27;89(4):171-5.
The LD(50) +/- S.E. of Reduced Iron, N.F. IX, given orally to albino rats was found to be 98.6 +/- 26.7 g. per kg. body weight, or over a hundredfold that of iron given as ferrous sulfate. The clinical and pathological signs of toxicity were somewhat similar to those of ferrous sulfate given under the same conditions. The results indicate that reduced iron could stand reinvestigation in respect of its practical value as a therapeutic agent with probably very low toxicity.
给白化大鼠口服美国国家处方集第九版中的还原铁，其半数致死量（LD(50)）±标准误为每千克体重98.6±26.7克，这是硫酸亚铁形式铁的半数致死量的一百多倍。在相同条件下，其毒性的临床和病理体征与硫酸亚铁的有些相似。结果表明，就还原铁作为一种可能毒性很低的治疗剂的实际价值而言，值得重新研究。
