Frankmölle W P, Knübel G, Moore R E, Patterson G M
Department of Chemistry, University of Hawaii, Honolulu 96822.
J Antibiot (Tokyo). 1992 Sep;45(9):1458-66. doi: 10.7164/antibiotics.45.1458.
Laxaphycins A and B are the major components in an antifungal mixture of cyclic peptides from the terrestrial blue-green alga Anabaena laxa FK-1-2. NMR and MS spectral studies coupled with amino acid analysis indicate that the gross structures of laxaphycins A and B are cyclic (Aoc-Hse-E-Dhb-Hyp-Hse-Phe-Leu-Ile-Ile-Leu-Gly) where Aoc is a 3-aminooctanoic acid residue and cyclic (Ala-Hleu-Gln-N-MeIle-Hasn-Thr-Pro-Leu-Thr-Ade-Val- Hleu) where Ade is a 3-aminodecanoyl unit, respectively. Laxaphycin E, a minor cyclic undecapeptide, differs in gross structure from laxaphycin A in possessing a 3-aminodecanoic acid unit (Ade) in lieu of Aoc, whereas laxaphycin D, a minor cyclic dodecapeptide, differs from laxaphycin B in possessing a 3-aminooctanoyl unit (Aoc) instead of an Ade unit.
拉沙霉素A和B是来自陆生蓝藻水华鱼腥藻FK-1-2的环肽抗真菌混合物中的主要成分。核磁共振（NMR）和质谱（MS）光谱研究以及氨基酸分析表明，拉沙霉素A和B的总体结构为环状（Aoc-Hse-E-Dhb-Hyp-Hse-Phe-Leu-Ile-Ile-Leu-Gly），其中Aoc是3-氨基辛酸残基，以及环状（Ala-Hleu-Gln-N-MeIle-Hasn-Thr-Pro-Leu-Thr-Ade-Val-Hleu），其中Ade分别是3-氨基癸酰基单元。拉沙霉素E是一种次要的环状十一肽，其总体结构与拉沙霉素A不同，它具有3-氨基癸酸单元（Ade）而非Aoc；而拉沙霉素D是一种次要的环状十二肽，它与拉沙霉素B不同，它具有3-氨基辛酰基单元（Aoc）而非Ade单元。
