Frankmölle W P, Larsen L K, Caplan F R, Patterson G M, Knübel G, Levine I A, Moore R E
Department of Chemistry, University of Hawaii, Honolulu 96822.
J Antibiot (Tokyo). 1992 Sep;45(9):1451-7. doi: 10.7164/antibiotics.45.1451.
Laxaphycins are responsible for the antifungal and cytotoxic activity of crude ethanolic extracts from the cultured blue-green alga Anabaena laxa. These cyclic peptides exhibit an unusual biological synergism when tested for antifungal or cytotoxic effects. The isolation procedure for the peptides, their characterization and biological activities are described here along with experiments demonstrating synergism between the two major laxaphycins.
松弛藻素负责培养的蓝绿藻——松散鱼腥藻的粗乙醇提取物的抗真菌和细胞毒性活性。这些环肽在测试抗真菌或细胞毒性作用时表现出不同寻常的生物协同作用。本文描述了这些肽的分离程序、特性和生物活性，以及证明两种主要松弛藻素之间协同作用的实验。
