新型抗病毒抗生素环病毒素B1和B2。II. 结构测定。
New antiviral antibiotics, cycloviracins B1 and B2. II. Structure determination.
作者信息
Tsunakawa M, Kotake C, Yamasaki T, Moriyama T, Konishi M, Oki T
机构信息
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1992 Sep;45(9):1472-80. doi: 10.7164/antibiotics.45.1472.
PMID:1429233
Abstract
The structures of novel antiviral antibiotics, cycloviracins B1 and B2 have been determined by means of chemical and spectroscopic methods including 2D NMR correlation spectroscopy. The antibiotics are unique macrocyclic diesters consisting of two D-glucoses, three 2-O-methyl-D-glucoses and two (C24 and C26) hydroxy fatty acids.
摘要
新型抗病毒抗生素环病毒素B1和B2的结构已通过包括二维核磁共振相关光谱法在内的化学和光谱方法确定。这些抗生素是独特的大环二酯，由两个D-葡萄糖、三个2-O-甲基-D-葡萄糖和两个（C24和C26）羟基脂肪酸组成。
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