新型抗病毒抗生素环病毒素B1和B2。I. 生产、分离、理化性质及生物活性
New antiviral antibiotics, cycloviracins B1 and B2. I. Production, isolation, physico-chemical properties and biological activity.
作者信息
Tsunakawa M, Komiyama N, Tenmyo O, Tomita K, Kawano K, Kotake C, Konishi M, Oki T
机构信息
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1992 Sep;45(9):1467-71. doi: 10.7164/antibiotics.45.1467.
PMID:1331014
Abstract
Kibdelosporangium albatum No. R761-7 (ATCC 55061) produced new antiviral antibiotics, cycloviracins B1 and B2. They show weak activity against Gram-positive bacteria and potent antiviral activity against herpes simplex virus type 1. Unique acylsaccharide structures were established for cycloviracins B1 and B2 by degradation and spectroscopic analysis.
摘要
白色栖孢囊菌R761-7号菌株（ATCC 55061）产生了新的抗病毒抗生素环病毒素B1和B2。它们对革兰氏阳性菌显示出微弱活性，对1型单纯疱疹病毒具有强大的抗病毒活性。通过降解和光谱分析确定了环病毒素B1和B2独特的酰基糖结构。
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