法替韦拉辛A1，由微黄色链霉菌2445号菌株产生的一种新型抗疱疹剂。I. 分类学、发酵、分离、物理化学性质及结构解析。

Fattiviracin A1, a novel antiherpetic agent produced by Streptomyces microflavus Strain No. 2445. I. Taxonomy, fermentation, isolation, physico-chemical properties and structure elucidation.

作者信息

Uyeda M, Yokomizo K, Miyamoto Y, Habib E E

机构信息

Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.

出版信息

J Antibiot (Tokyo). 1998 Sep;51(9):823-8. doi: 10.7164/antibiotics.51.823.

DOI:10.7164/antibiotics.51.823

PMID:9820232

Abstract

A novel antiherpetic agent, fattiviracin A1, was isolated from the culture broth of strain No. 2445 identified as Streptomyces microflavus. It was purified through 1-butanol extraction, column chromatographies on Diaion HP-10 and silica gel and HPLC using a reverse phase column. The structure of fattiviracin A1 was determined by several spectroscopic experiments and chemical degradations. It is a new macrocyclic diester consisting of four D-glucose units and two (C24 and C33) hydroxy fatty acids. It is closely related to cycloviracins B1 and B2, but differs from these known compounds in both the length of its side chain and the sugar moiety.

摘要

一种新型抗疱疹剂法替韦拉辛A1，是从鉴定为微黄链霉菌的2445号菌株的培养液中分离得到的。它通过正丁醇萃取、Diaion HP - 10和硅胶柱色谱以及使用反相柱的高效液相色谱法进行纯化。法替韦拉辛A1的结构通过多项光谱实验和化学降解得以确定。它是一种由四个D - 葡萄糖单元和两个（C24和C33）羟基脂肪酸组成的新型大环二酯。它与环维拉克菌素B1和B2密切相关，但在侧链长度和糖部分均与这些已知化合物不同。