Bianchi C, Airaudo C B, Gayte-Sorbier A
Pharmacy of Centre Hospitalier Spécialisé Valvert, Marseilles, France.
J Clin Pharm Ther. 1992 Aug;17(4):223-7. doi: 10.1111/j.1365-2710.1992.tb01296.x.
The compatibilities of dipotassium clorazepate and midazolam hydrochloride with polyvinyl chloride (PVC) bags have been studied and compared with those observed with glass flasks. At room temperature, dipotassium clorazepate showed chemical instability which was independent of the container. At 4 degrees C, dipotassium clorazepate showed no decrease in concentration over 12 h, both in 5% dextrose solution and 0.9% sodium chloride solutions. When stored for longer periods of up to 72 h, a slight decrease not exceeding 5% was observed. The compatibility of midazolam with the PVC bags was found to be good at room temperature. It was slightly better in 5% dextrose solution than in 0.9% sodium chloride solution. High sorption of the drug was observed at pH 7.0 when the primary ring structure is maintained. The results make it possible for the hospital pharmacist to prepare dipotassium chlorazepate salt and midazolam admixtures up to 3 days before administration, provided the former are stocked in a refrigerator and the latter are prepared in dextrose isotonic solutions.
已对氯氮䓬二钾与盐酸咪达唑仑在聚氯乙烯（PVC）袋中的相容性进行了研究，并与在玻璃瓶中观察到的情况进行了比较。在室温下，氯氮䓬二钾表现出化学不稳定性，且与容器无关。在4℃时，氯氮䓬二钾在5%葡萄糖溶液和0.9%氯化钠溶液中12小时内浓度均未降低。储存长达72小时时，观察到有不超过5%的轻微降低。发现咪达唑仑与PVC袋在室温下相容性良好。在5%葡萄糖溶液中比在0.9%氯化钠溶液中稍好。当维持主环结构时，在pH 7.0时观察到药物有较高吸附。这些结果使医院药剂师能够在给药前3天制备氯氮䓬二钾盐和咪达唑仑混合物，前提是前者储存在冰箱中，后者用葡萄糖等渗溶液配制。
