人类脑脱髓鞘疾病中类似乳头多瘤空泡病毒的颗粒
PARTICLES RESEMBLING PAPOVA VIRUSES IN HUMAN CEREBRAL DEMYELINATING DISEASE.
作者信息
ZURHEIN G, CHOU S M
出版信息
Science. 1965 Jun 11;148(3676):1477-9. doi: 10.1126/science.148.3676.1477.
Abstract
Degenerated brain tissue obtained from a deceased patient who had progressive multifocal leukoencephalopathy had been fixed in formalin prior to processing for electron microscopy. In ultrathin sections virus-like particles resembling papova virions were frequently observed in glial nuclei. Correlation with light-microscopy findings suggests that demyelination resulted from the cytocidal effect of the virus on oligodendroglia.
摘要
从一名患有进行性多灶性白质脑病的已故患者身上获取的退化脑组织，在进行电子显微镜检查处理之前已用福尔马林固定。在超薄切片中，经常在神经胶质细胞核中观察到类似乳头多瘤空泡病毒颗粒的病毒样颗粒。与光学显微镜检查结果的相关性表明，脱髓鞘是由病毒对少突胶质细胞的杀细胞作用导致的。
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