• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

人类脱髓鞘性脑病中的多瘤病毒样病毒颗粒

POLYOMA-LIKE VIRIONS IN HUMAN DEMYELINATING BRAIN DISEASE.

作者信息

HOWATSON A F, NAGAI M, ZURHEIN G M

出版信息

Can Med Assoc J. 1965 Aug 28;93(9):379-86.

PMID:14339302
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1928746/
Abstract

Specimens of brain tissue obtained at autopsy from three patients suffering from progressive multifocal leukoencephalopathy (PML) were examined by electron microscopy. In specimens from all three cases particles similar to those of the papova virus group were present, confirming previous observations. By the negative staining method it was possible to define the morphological characteristics of the particles more precisely and it was shown that they are structurally similar to virions of the polyoma-SV40-K type. The need is emphasized for obtaining fresh unfixed diseased tissue from persons suffering from PML in order that the biological properties of the particles can be investigated.

摘要

对3例进行性多灶性白质脑病（PML）患者尸检时获取的脑组织标本进行了电子显微镜检查。在所有3例的标本中，均发现了与乳头多瘤空泡病毒组相似的颗粒，证实了先前的观察结果。通过负染色法能够更精确地确定这些颗粒的形态特征，结果表明它们在结构上与多瘤病毒 - SV40 - K型病毒粒子相似。强调需要从PML患者获取新鲜的未固定病变组织，以便能够研究这些颗粒的生物学特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bf/1928746/aad3b3c442a1/canmedaj01115-0008-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bf/1928746/a86a22244b46/canmedaj01115-0004-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bf/1928746/e660782d6acc/canmedaj01115-0005-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bf/1928746/bd4b97a7583d/canmedaj01115-0006-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bf/1928746/131aa54b5bfd/canmedaj01115-0007-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bf/1928746/771205f1d56f/canmedaj01115-0007-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bf/1928746/aad3b3c442a1/canmedaj01115-0008-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bf/1928746/a86a22244b46/canmedaj01115-0004-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bf/1928746/e660782d6acc/canmedaj01115-0005-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bf/1928746/bd4b97a7583d/canmedaj01115-0006-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bf/1928746/131aa54b5bfd/canmedaj01115-0007-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bf/1928746/771205f1d56f/canmedaj01115-0007-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5bf/1928746/aad3b3c442a1/canmedaj01115-0008-a.jpg

相似文献

1
POLYOMA-LIKE VIRIONS IN HUMAN DEMYELINATING BRAIN DISEASE.人类脱髓鞘性脑病中的多瘤病毒样病毒颗粒
Can Med Assoc J. 1965 Aug 28;93(9):379-86.
2
PARTICLES RESEMBLING PAPOVA VIRUSES IN HUMAN CEREBRAL DEMYELINATING DISEASE.人类脑脱髓鞘疾病中类似乳头多瘤空泡病毒的颗粒
Science. 1965 Jun 11;148(3676):1477-9. doi: 10.1126/science.148.3676.1477.
3
AN IMPROVEMENT FOR ELECTRON MICROSCOPIC RESOLUTION OF POLYOMA VIRUS CAPSOMERES.多瘤病毒衣壳粒电子显微镜分辨率的一种改进方法。
Virology. 1964 Sep;24:125-6. doi: 10.1016/0042-6822(64)90160-6.
4
Polyoma-like virions in a human demyelinating disease.人类脱髓鞘疾病中的多瘤病毒样病毒粒子
Acta Neuropathol. 1967 Mar 6;8(1):57-68. doi: 10.1007/BF00686650.
5
[LEUKODYSTROPHY WITH ORTHOCHROMATIC BREAKDOWN PRODUCTS. A CONTRIBUTION TO PELIZAEUS-MERZBACHER DISEASE].[伴有正染性崩解产物的脑白质营养不良。对佩利措伊斯-梅茨巴赫病的一项贡献]
Virchows Arch Pathol Anat Physiol Klin Med. 1965 Feb 15;338:371-94.
6
[Brain diseases in man and virions--capsomer count of PML (progressive multifocal leukoencephalopathy) virions].[人类脑部疾病与病毒粒子——进行性多灶性白质脑病病毒粒子的壳粒计数]
Shinkei Kenkyu No Shimpo. 1971;15(2):495-9.
7
Progressive multifocal leukoencephalopathy. Neuropathology and virus isolation.进行性多灶性白质脑病。神经病理学与病毒分离
Acta Pathol Jpn. 1981 Nov;31(6):953-61.
8
Morphological demonstration of the first phase of polyomavirus replication in oligodendroglia cells of human brain in progressive multifocal leukoencephalopathy (PML).多瘤病毒在进行性多灶性白质脑病（PML）患者大脑少突胶质细胞中复制第一阶段的形态学证明
Acta Neuropathol. 1980;49(2):133-43. doi: 10.1007/BF00690753.
9
Virions associated with four japanese cases of progressive multifocal leukoencephalopathy.与4例日本进行性多灶性白质脑病病例相关的病毒颗粒。
Int Arch Allergy Appl Immunol. 1969;36:Suppl:488-514.
10
AN AUTOPSY CASE OF LEUCODYSTROPHY OF KRABBE TYPE.一例克拉伯型脑白质营养不良尸检病例。
Acta Pathol Jpn. 1963 Jul;13:195-9. doi: 10.1111/j.1440-1827.1963.tb01924.x.

引用本文的文献

1
Molecular biology, epidemiology, and pathogenesis of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain.进行性多灶性白质脑病，即人类大脑中由 JC 病毒引起的脱髓鞘疾病的分子生物学、流行病学和发病机制。
Clin Microbiol Rev. 2012 Jul;25(3):471-506. doi: 10.1128/CMR.05031-11.
2
Viral-associated trichodysplasia spinulosa: a case with electron microscopic and molecular detection of the trichodysplasia spinulosa-associated human polyomavirus.病毒相关性棘状毛发发育不良：1例通过电子显微镜和分子检测发现棘状毛发发育不良相关人多瘤病毒的病例
J Cutan Pathol. 2011 May;38(5):420-31. doi: 10.1111/j.1600-0560.2010.01664.x. Epub 2011 Jan 19.
3

本文引用的文献

1
Papova virus group.乳头多瘤空泡病毒组
Science. 1962 Mar 30;135(3509):1128-30. doi: 10.1126/science.135.3509.1128.
2
An electron microscope study of polyoma virus in hamster kidney.仓鼠肾中多瘤病毒的电子显微镜研究
J Biophys Biochem Cytol. 1960 Jul;7(4):753-60. doi: 10.1083/jcb.7.4.753.
3
[PROGRESSIVE MULTIFOCAL LEUKO-ENCEPHALOPATHY].[进行性多灶性白质脑病]
The remote effects of cancer on the nervous system.
癌症对神经系统的远程影响。
Proc R Soc Med. 1967 Jul;60(7):690-2. doi: 10.1177/003591576706000724.
4
Another virus in C.N.s.?中枢神经系统中还有另一种病毒？
Br Med J. 1966 Apr 30;1(5495):1062-3.
5
Diagnostic virology using electron microscopic techniques.运用电子显微镜技术的诊断病毒学
Adv Virus Res. 1982;27:1-69. doi: 10.1016/s0065-3527(08)60432-7.
6
Subacute sclerosing leuco-encephalitis. Electron microscopic finding in two cases with inclusion bodies.亚急性硬化性全脑炎。两例伴有包涵体的电子显微镜检查结果
Acta Neuropathol. 1967 Jul 5;8(4):362-80. doi: 10.1007/BF00696673.
7
[Pseudosystemic lesions in "atypical" encephalitides].["非典型"脑炎中的假性系统性病变]
Acta Neuropathol. 1967 May;8(2):185-209. doi: 10.1007/BF00687695.
8
Intracranial Hodgkin's disease shown by radioisotope scan.放射性同位素扫描显示的颅内霍奇金病。
J Neurol Neurosurg Psychiatry. 1969 Aug;32(4):313-6. doi: 10.1136/jnnp.32.4.313.
9
Virological aspects of neurological disease.神经疾病的病毒学方面
Postgrad Med J. 1969 Jun;45(524):351-60. doi: 10.1136/pgmj.45.524.351.
10
A short fatal illness for discussion.一种用于讨论的短期致命疾病。
Br Med J. 1969 Apr 5;2(5648):33-8.
Rev Med Suisse Romande. 1964 Feb;84:126-36.
4
A COMPARATIVE STUDY OF POLYOMA AND PAPILLOMA VIRUSES.多瘤病毒与乳头瘤病毒的比较研究
Virology. 1963 Oct;21:258-63. doi: 10.1016/0042-6822(63)90265-4.
5
PROGRESSIVE MULTIFOCAL LEUCOENCEPHALOPATHY AND PRIMARY HYPERSPLENISM. WITH A NOTE ON THE ASSOCIATION BETWEEN DISEASE OF THE RETICULOENDOTHELIAL SYSTEM AND PROGRESSIVE MULTIFOCAL LEUCOENCEPHALOPATHY.进行性多灶性白质脑病与原发性脾功能亢进。附关于网状内皮系统疾病与进行性多灶性白质脑病之间关联的说明。
J Clin Pathol. 1963 Sep;16(5):405-18. doi: 10.1136/jcp.16.5.405.
6
Progressive multifocal leukoencephalopathy.进行性多灶性白质脑病
N Engl J Med. 1961 Oct 26;265:815-23. doi: 10.1056/NEJM196110262651701.
7
Proposals.提案。
Cold Spring Harb Symp Quant Biol. 1962;27:49-50. doi: 10.1101/sqb.1962.027.001.007.
8
Infectious leukoencephalitis. A critical comparison of certain experimental and naturally-occurring viral leukoencephalitides with experimental allergic encephalomyelitis.感染性脑白质炎。某些实验性和自然发生的病毒性脑白质炎与实验性变应性脑脊髓炎的关键比较。
J Neuropathol Exp Neurol. 1962 Oct;21:491-518.
9
Cerebral demyelination associated with disorders of the reticuloendothelial system.与网状内皮系统疾病相关的脑脱髓鞘病变
Lancet. 1959 Oct 10;2(7102):524-9. doi: 10.1016/s0140-6736(59)91774-x.
10
A negative staining method for high resolution electron microscopy of viruses.一种用于病毒高分辨率电子显微镜观察的负染色方法。
Biochim Biophys Acta. 1959 Jul;34:103-10. doi: 10.1016/0006-3002(59)90237-9.