Jänisch W, Gerlach H, Holzhausen H J
Zentralbl Allg Pathol. 1977;121(1-2):33-9.
Two cases of multifocal progressive leukoencephalopathy are reported. A 62 years old patient suffering from lymphosarcomatosis for more than 5 years developed neurological symptoms and died 7 weeks after their onset. In a 44 years old patient a kidney transplantation was performed. 6 months after that operation he developed a disorder of the central nervous system and died 3 weeks later. Post-mortem examinations revealed the characteristic morphological findings of multifocal leukoencephalopathy in both the cases. Electron microscopic examination of the brain tissue obtained at autopsy demonstrated virions in paracristalline arrangement within the nuclei of oligodendrocytes. These findings are identical with those reported in literature, that were regarded as papova-viruses. Therefore, it is suggested to name the disease a papova-virus-encephalitis.
报告了两例多灶性进行性白质脑病。一名62岁的患者患淋巴肉瘤病5年多，出现神经症状，发病7周后死亡。一名44岁的患者接受了肾脏移植。术后6个月，他出现中枢神经系统紊乱，3周后死亡。尸检在两例中均发现了多灶性白质脑病的特征性形态学表现。对尸检获得的脑组织进行电子显微镜检查，显示少突胶质细胞核内有呈准晶体排列的病毒颗粒。这些发现与文献报道的相同，文献中认为这些病毒为乳头多瘤空泡病毒。因此，建议将该疾病命名为乳头多瘤空泡病毒性脑炎。
