Chow J, Hartley R B, Jagger C, Dilly S A
Department of Histopathology, St George's Hospital Medical School, London.
J Clin Pathol. 1992 Oct;45(10):880-4. doi: 10.1136/jcp.45.10.880.
To determine the role of intercellular adhesion molecule-1 (ICAM-1) in immune mediated damage in glomerulonephritis, and whether its expression correlates with disease activity.
Fifty three renal biopsy specimens from a range of non-immune renal disease and low grade and high grade glomerulonephritides were stained with ICAM-1. Positivity was assessed in the tubules. Tubular damage and accompanying interstitial inflammation were also noted. The ICAM-1 positivity in damaged and undamaged tubules was correlated with the three groups of renal disease.
ICAM-1 positivity in undamaged tubules was observed in glomerulonephritis, and this showed a strong correlation with disease activity. In contrast, ICAM-1 positivity on damaged tubules correlated with evidence of chronic tubular damage, and was seen in a large proportion of cases, regardless of the underlying disease. There was no correlation between ICAM-1 positivity and a local lymphocytic infiltrate.
ICAM-1 probably has an important role in the pathogenesis of glomerulonephritis. Its expression may be secondary to cytokines released by cells participating in the glomerular damage. As these cytokines also influence tubule function, tubular ICAM-1 expression may be a marker of the extent of tubular disturbance in glomerulonephritis.
确定细胞间黏附分子-1（ICAM-1）在肾小球肾炎免疫介导损伤中的作用，以及其表达是否与疾病活动相关。
用ICAM-1对53份来自一系列非免疫性肾病以及轻度和重度肾小球肾炎的肾活检标本进行染色。评估肾小管中的阳性情况。同时记录肾小管损伤及伴随的间质炎症。将受损和未受损肾小管中的ICAM-1阳性情况与三组肾病进行关联分析。
在肾小球肾炎中观察到未受损肾小管中有ICAM-1阳性，且这与疾病活动密切相关。相比之下，受损肾小管上的ICAM-1阳性与慢性肾小管损伤的证据相关，并且在大部分病例中都可见，无论潜在疾病如何。ICAM-1阳性与局部淋巴细胞浸润之间无相关性。
ICAM-1可能在肾小球肾炎的发病机制中起重要作用。其表达可能继发于参与肾小球损伤的细胞释放的细胞因子。由于这些细胞因子也影响肾小管功能，肾小管ICAM-1表达可能是肾小球肾炎中肾小管紊乱程度的一个标志物。
