Boudet F
Sanofi-Pasteur, Research Department, Marcy L'Etoile, France.
J Comp Pathol. 2010 Jan;142 Suppl 1:S70-3. doi: 10.1016/j.jcpa.2009.10.005. Epub 2009 Nov 7.
A decline in protective immune responses following vaccination is one of the main features of immunosenescence. Improved vaccine candidates for elderly adults are thus urgently needed. For scientific and regulatory requirements, such new vaccines must first be evaluated at the preclinical level, and there is a continuing quest for the ideal animal model with which to perform such studies. The main advantages and limitations of murine models, those most commonly used for human vaccine research, and of large animal models are reviewed and discussed.
疫苗接种后保护性免疫反应的下降是免疫衰老的主要特征之一。因此，迫切需要为老年人研发更好的候选疫苗。出于科学和监管要求，此类新疫苗必须首先在临床前水平进行评估，并且一直在寻找用于开展此类研究的理想动物模型。本文综述并讨论了最常用于人类疫苗研究的小鼠模型和大型动物模型的主要优缺点。
