亚急性皮肤型红斑狼疮中与Ro(SS-A)抗体相关的特征性皮肤直接免疫荧光模式。
A characteristic cutaneous direct immunofluorescent pattern associated with Ro(SS-A) antibodies in subacute cutaneous lupus erythematosus.
作者信息
Valeski J E, Kumar V, Forman A B, Beutner E H, Chorzelski T P
机构信息
IMMCO Diagnostics Inc., Buffalo, NY 14223.
出版信息
J Am Acad Dermatol. 1992 Aug;27(2 Pt 1):194-8. doi: 10.1016/0190-9622(92)70169-g.
BACKGROUND
Antibodies to Ro(SS-A) are present in most patients with subacute cutaneous lupus erythematosus (SCLE). Patients with SCLE also have cutaneous immune deposits. However, no correlation of Ro(SS-A) antibodies with immune deposits in skin biopsy specimens has been described.
OBJECTIVE
The purpose of this study is to describe characteristic direct immunofluorescence (IF) findings in 32 patients and their association with serum antibodies and clinical diagnosis.
METHODS
Serum from patients with characteristic cutaneous direct IF findings was examined for antinuclear antibodies by indirect IF and for antibodies to ribonucleoprotein, Sm, Ro(SS-A), and La(SS-B) by gel immunodiffusion.
RESULTS
Twenty-two of 32 patients who exhibited discrete speckled IgG staining predominantly, but not exclusively, of the basal cell cytoplasm had SCLE. Ro(SS-A) antibodies were identified in 23 of 26 patients and Ro(SS-A) and/or La(SS-B) in 25 of 26 patients.
CONCLUSION
Direct IF staining characterized by discrete speckled IgG deposits in the basal cell cytoplasm is associated with Ro(SS-A) antibodies and SCLE.
背景
大多数亚急性皮肤型红斑狼疮（SCLE）患者体内存在抗Ro（SS - A）抗体。SCLE患者的皮肤也有免疫沉积物。然而，尚未有关于Ro（SS - A）抗体与皮肤活检标本中免疫沉积物相关性的描述。
目的
本研究旨在描述32例患者的特征性直接免疫荧光（IF）结果及其与血清抗体和临床诊断的关联。
方法
对具有特征性皮肤直接IF结果的患者血清进行间接IF检测抗核抗体，并通过凝胶免疫扩散检测抗核糖核蛋白、Sm、Ro（SS - A）和La（SS - B）抗体。
结果
32例患者中，22例主要在基底细胞胞质中呈现离散的斑点状IgG染色（但不仅限于此），这些患者患有SCLE。26例患者中有23例检测到Ro（SS - A）抗体，26例患者中有25例检测到Ro（SS - A）和/或La（SS - B）抗体。
结论
以基底细胞胞质中离散的斑点状IgG沉积物为特征的直接IF染色与Ro（SS - A）抗体和SCLE相关。
Zotero 插件