Magnussen H, Rabe K F
Grosshansdorf Hospital, Center for Pneumology and Thoracic Surgery, Germany.
J Allergy Clin Immunol. 1992 Nov;90(5):846-51. doi: 10.1016/0091-6749(92)90111-e.
We compared in a randomized, double-blind study the protective effect of low doses of fenoterol on the airway response to exercise during cold air breathing and an inhalation challenge with methacholine. In six asymptomatic asthmatic persons (mean age, 20.3 years) exercise and methacholine challenges were performed under control conditions and 15 minutes after the inhalation from a metered-dose inhaler of either placebo or 30, 50, 100, and 200 micrograms fenoterol, resulting in 12 separate study sessions within a 3-week period. Airway response was determined by measuring specific airway resistance (sRaw). Exercise tests were standardized by maintaining a constant respiratory heat exchange, with an average (range) of 1.28 (1.15 to 1.45) kcal/min. Methacholine was inhaled at increasing doses until sRaw had doubled (PD100sRaw). Mean postexertional increase of sRaw (SD) after control conditions, placebo, and 30, 50, 100, and 200 micrograms fenoterol aerosol was 27.8 (6.9), 28.9 (10.0), 7.20 (2.7), 9.33 (3.8), 5.57 (2.3), and 5.28 (1.6) cm H2O.s. Fenoterol aerosol was equally effective at all doses administered, whereas methacholine-induced bronchoconstriction was attenuated in a dose-dependent manner. From these observations we suggest that low-dose fenoterol protects against bronchoconstriction induced by exercise, a naturally occurring stimulus reflecting airway hyperresponsiveness.
在一项随机双盲研究中，我们比较了低剂量非诺特罗对冷空气呼吸期间运动诱发的气道反应以及对乙酰甲胆碱吸入激发试验的保护作用。在6名无症状哮喘患者（平均年龄20.3岁）中，在对照条件下以及从定量吸入器吸入安慰剂或30、50、100和200微克非诺特罗15分钟后，进行运动和乙酰甲胆碱激发试验，在3周内共进行12次独立的研究时段。通过测量比气道阻力（sRaw）来确定气道反应。通过维持恒定的呼吸热交换来标准化运动试验，平均（范围）为1.28（1.15至1.45）千卡/分钟。以递增剂量吸入乙酰甲胆碱，直至sRaw加倍（PD100sRaw）。对照条件、安慰剂以及30、50、100和200微克非诺特罗气雾剂后，运动后sRaw的平均增加值（标准差）分别为27.8（6.9）、28.9（10.0）、7.20（2.7）、9.33（3.8）、5.57（2.3）和5.28（1.6）厘米水柱·秒。所有给药剂量的非诺特罗气雾剂效果相同，而乙酰甲胆碱诱发的支气管收缩呈剂量依赖性减弱。根据这些观察结果，我们认为低剂量非诺特罗可预防运动诱发的支气管收缩，运动是一种反映气道高反应性的自然刺激。
