Magnussen H, Rabe K F
Krankenhaus Grosshansdorf, Zentrum für Pneumologie und Thoraxchirurgie, Germany.
Clin Exp Allergy. 1992 Jul;22(7):690-3. doi: 10.1111/j.1365-2222.1992.tb00192.x.
Sixteen subjects with mild stable asthma participated in a randomized double blind study on the effects of low dose fenoterol against histamine induced bronchoconstriction. Fenoterol aerosol at concentrations of 10, 50 and 200 micrograms and placebo were delivered at random through a metered dose inhaler as a single dose 30 min before histamine challenges on four separate occasions. Compared to placebo a fenoterol dose of 10 micrograms provided significant bronchodilatation (sRaw [s.d.] 8.3 [2.73] vs 6.3 [1.74] cm H2O* s [P less than 0.05]) and protection (PC100 sRaw [s.e.m.] 0.72 (1.31) vs 1.45 (1.39) mg/ml). The bronchodilatory and protective actions of fenoterol were more pronounced after the inhalation of 200 micrograms (P less than 0.05) with no difference between 10 and 50 micrograms fenoterol aerosol. The magnitude of bronchodilatation and protection was not correlated (r = 0.15). The results from this acute study may suggest that fenoterol at doses up to 20 times lower than routinely recommended may be an effective treatment in mild asthmatics.
16名患有轻度稳定型哮喘的受试者参与了一项关于低剂量非诺特罗对抗组胺诱导的支气管收缩作用的随机双盲研究。在组胺激发试验前30分钟，通过定量吸入器随机给予浓度为10、50和200微克的非诺特罗气雾剂及安慰剂，均为单次剂量，共进行4次独立试验。与安慰剂相比，10微克剂量的非诺特罗可产生显著的支气管扩张作用（比气道阻力[s.d.] 8.3 [2.73] 对比 6.3 [1.74] cm H₂O*s [P < 0.05]）和保护作用（使组胺激发试验比气道阻力下降100%时的组胺浓度[标准误] 0.72 (1.31) 对比 1.45 (1.39) mg/ml）。吸入200微克非诺特罗后，其支气管扩张和保护作用更为显著（P < 0.05），而10微克和50微克剂量的非诺特罗气雾剂之间无差异。支气管扩张程度和保护作用之间无相关性（r = 0.15）。这项急性研究的结果可能表明，剂量比常规推荐低20倍的非诺特罗可能是轻度哮喘患者的一种有效治疗方法。
