雾化吸入和口服非诺特罗对哮喘患者组胺和乙酰甲胆碱激发试验的影响。
Effect of aerosol and oral fenoterol on histamine and methacholine challenge in asthmatic subjects.
作者信息
Salome C M, Schoeffel R E, Woolcock A J
出版信息
Thorax. 1981 Aug;36(8):580-4. doi: 10.1136/thx.36.8.580.
Abstract
In order to determine the effect of drugs on bronchial hyperreactivity in subjects with asthma, 12 atopic asthmatic volunteers underwent bronchial challenge with either histamine or methacholine on three separate days. Before the challenges no medication was given on the first day, on the second 400 microgram of aerosol fenoterol and on the third 5 mg of oral fenoterol were administered. The aerosol fenoterol caused the dose response curves to both histamine and methacholine to be shifted to the right in all subjects. The oral dose produced no significant change from the control values. The slope of the dose response curves was not altered by either the oral or the aerosol drug. It is concluded that aerosol but not oral fenoterol in the clinical dosage, causes a change in the sensitivity but not in the reactivity of the airway of patients with atopic asthma.
摘要
为了确定药物对哮喘患者支气管高反应性的影响，12名特应性哮喘志愿者在三个不同的日子分别接受了组胺或乙酰甲胆碱的支气管激发试验。在激发试验前，第一天未给药，第二天给予400微克的雾化非诺特罗，第三天给予5毫克的口服非诺特罗。雾化非诺特罗使所有受试者对组胺和乙酰甲胆碱的剂量反应曲线均右移。口服剂量与对照值相比无显著变化。口服或雾化药物均未改变剂量反应曲线的斜率。得出的结论是，临床剂量的雾化而非口服非诺特罗会导致特应性哮喘患者气道敏感性发生变化，但气道反应性未改变。
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