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Q热病原体(伯氏考克斯氏体)会引发A29、B12血管炎吗?

[Is A29, B12 vasculitis caused by the Q fever agent? (Coxiella burnetii)].

作者信息

Kuhne F, Morlat P, Riss I, Dominguez M, Hostyn P, Carniel N, Paix M A, Aubertin J, Raoult D, Le Rebeller M J

机构信息

Service d'Ophtalmologie, Hôpital Pellegrin, Bordeaux.

出版信息

J Fr Ophtalmol. 1992;15(5):315-21.

PMID:1430809
Abstract

The authors describe the first two cases, to their knowledge, of retinal vasculitis, associated with Q fever. The first case was a chronic infection induced by Coxiella burnetii associated with HLA group A29 and B12; in the second case, the phenotype was B12. The authors tried to determine whether this agent could be the "Birdshot chorioretinopathy" promoting factor. Several epidemiologic findings tend to prove that Q fever is not the only cause. On the other hand, its similarity with rickettsia, the fact that it is found in patients with vasculitis, suggest that it could be one of the initial causal factors.

摘要

据作者所知,他们描述了首例与Q热相关的视网膜血管炎病例。第一例是由伯氏考克斯体引起的慢性感染,与HLA A29组和B12相关;第二例的表型为B12。作者试图确定这种病原体是否可能是“鸟枪弹样脉络膜视网膜病变”的促发因素。多项流行病学研究结果倾向于证明Q热并非唯一病因。另一方面,它与立克次体的相似性,以及在血管炎患者中被发现这一事实,表明它可能是初始病因之一。

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