François J
Ann Ophthalmol. 1977 Sep;9(9):1075-80.
Chronic as well as acute glaucoma can be induced by corticosteroids. The hypertensive response to the topical corticosteroid test is not genetically determined. The pathogenesis of the corticosteroid glaucoma can be explained by clones of goniocytes, which contain mucopolysaccharides sensitive to hyaluronidase. When these mucopolysaccharides are polymerized, they retain water and when they are depolymerized, they loose water. As the corticosteroid strengthen the lysosomal membranes, the retained catabolising enzymes prevent the catabolism of the mucopolysaccharides, which tend to accumulate in a more polymerized and more hydrophilic form.
慢性和急性青光眼都可由皮质类固醇诱发。局部皮质类固醇试验的高血压反应并非由基因决定。皮质类固醇性青光眼的发病机制可用角细胞克隆来解释，这些角细胞含有对透明质酸酶敏感的粘多糖。当这些粘多糖聚合时，它们会保留水分，而解聚时则会失去水分。由于皮质类固醇会强化溶酶体膜，保留的分解代谢酶会阻止粘多糖的分解代谢，粘多糖往往会以更聚合、更亲水的形式积累。
